ArticleJournal of physiology and biochemistry2013
Thiamine deficiency induces oxidative stress in brain mitochondria of Mus musculus.
Article in Journal of physiology and biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Potential of Benfotiamine in the treatment of neuropsychological disorders.Molecular biology reports · 2025Review
- Protective Role of Thiamine Pyrophosphate Against Erlotinib-Induced Oxidative and Inflammatory Damage in Rat Optic Nerve.Biomedicines · 2025Article
- Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Thiamine (Vitamin B1)-An Essential Health Regulator.Nutrients · 2025Review
- Role of Vitamin B in Healthy Ageing and Disease.Sub-cellular biochemistry · 2024Review
- Supplemental thiamine as a practical, potential way to prevent Alzheimer's disease from commencing.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes.Diabetes · 2019Article
- Alteration in MDA, GSH level and hematological changes due to thiamine deficiency inInterdisciplinary toxicology · 2018Article
- Thiamine Deficiency Induced Dietary Disparity Promotes Oxidative Stress and Neurodegeneration.Indian journal of clinical biochemistry : IJCB · 2018Article
- Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10.Environmental science and pollution research international · 2018Article
- Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy.Molecular neurobiology · 2017Review
- Article
- The role of astrocyte mitochondria in differential regional susceptibility to environmental neurotoxicants: tools for understanding neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Role of astrocytes in thiamine deficiency.Metabolic brain disease · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present investigation evaluates the changes in the levels of antioxidant enzymes, lipid peroxidation (LPO), and protein carbonyl content (PCC) in brain mitochondria following thiamine deficiency (TD). The study was carried out on Mus musculus allocated into three groups, namely control and thiamine-deficient group for 8 (TD 8) and 10 (TD 10) days. The LPO was measured in terms of reduced glutathione (GSH) and thiobarbituric acid reactive substance (TBARS). Antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured biochemically. A significant increase in the TBARS (p < 0.0001) and PCC (p < 0.001) levels in group II (TD 8) and group III (TD 10) animals was observed in comparison to controls. The GSH levels were found to be reduced in both the treated groups compared to the control. A significant reduction in the activities of SOD was also observed in group II (p < 0.01) and group III (p < 0.0001) animals in comparison to the control. Enzymatic activities of CAT (p < 0.001) and GPx (p < 0.05) were found to be significantly reduced in group III (TD 10) in comparison to the control. In conclusion, reduction in the activities of antioxidant enzymes as well as an increase in LPO and PCC following TD implies oxidative stress in brain mitochondria that may further leads to neurodegeneration.
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