ReviewPflugers Archiv : European journal of physiology2013
Sex differences in exercise-induced cardiac hypertrophy.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- New applications of cardiopulmonary exercise testing parameters characterize age-related changes in exercise performance during adolescence.Frontiers in cardiovascular medicine · 2026Article
- Regulatory mechanisms of exercise-induced physiological cardiac hypertrophy: progress and prospects.Frontiers in cardiovascular medicine · 2025Review
- Investigation of left atrial mechanical function and left ventricular systolic and diastolic parameters in athletes performing resistance exercise and combined exercise.BMC cardiovascular disorders · 2024Article
- Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.Clinical science (London, England : 1979) · 2022Article
- Cardiodiagnostic sex-specific differences of the female athlete in sports cardiology.American heart journal plus : cardiology research and practice · 2022Article
- Sex Differences in VOInternational journal of environmental research and public health · 2022Review
- A framework for developing sex-specific engineered heart models.Nature reviews. Materials · 2022Review
- Matters of the heart: Cellular sex differences.Journal of molecular and cellular cardiology · 2021Review
- Sex-Specific Impacts of Exercise on Cardiovascular Remodeling.Journal of clinical medicine · 2021Review
- Gender Difference of Cardiac Remodeling in University Athletes: Results from 2015 Gwangju Summer Universiade.Korean circulation journal · 2021Article
- Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodeling or Arrhythmogenicity.Antioxidants (Basel, Switzerland) · 2021Article
- Cardiac adaptation to exercise training in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Gender Differences in Cardiac Hypertrophy.Journal of cardiovascular translational research · 2020Review
- Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice.PloS one · 2020Article
- Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise.Current cardiology reviews · 2020Review
- A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.Journal of the Endocrine Society · 2019Article
- Sex Differences in Morphological and Functional Aspects of Exercise-Induced Cardiac Hypertrophy in a Rat Model.Frontiers in physiology · 2019Article
- The Female Athlete's Heart: Facts and Fallacies.Current treatment options in cardiovascular medicine · 2018Review
- Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance.Endocrine reviews · 2018Review
- A Memory of Early Life Physical Activity Is Retained in Bone Marrow of Male Rats Fed a High-Fat Diet.Frontiers in physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physiological cardiac hypertrophy (PCH), induced by intensive exercise or pregnancy, differs substantially from the pathological form of myocardial hypertrophy, accruing after aortic stenosis or chronic arterial hypertension. In contrast to pathological forms of cardiac hypertrophy, exercise-induced increase of left ventricular mass is related to cardiac myocytes enlargement, with no apparent sign of fibrosis or apoptosis, and does usually not result in cardiac failure. Recently published results obtained from various animal studies documented clear sex-specific regulation of exercise-induced cardiac hypertrophy in rodents, with a pronounced hypertrophic response to training load observed in female animals when compared to male littermate. In addition to increased cardiac hypertrophic response, females exhibited augmented lipolytic activity measured in adipose tissue in response to exercise, resulting in increased plasma free fatty acid levels, measured after training. Importantly, sex-specific differences in adipose tissue lipolysis and systemic fat metabolism induced by intensive training were also confirmed in human studies, performed on athletes and healthy volunteers. Since development of PCH during the physical training is accompanied by enhanced fatty acid oxidation and reduced glucose uptake, intensive lipolytic activity, measured in female adipose tissue could explain, at least in part, sex-specific differences observed in hypertrophic response to exercising. Given that sex hormones, such as estrogens and testosterone, in addition to their role in the regulation of adipose tissue metabolism, were also reported to modulate development of pathological myocardial hypertrophy, one may expect also a putative contribution of sex hormones in processes regulating the development and progression of PCH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.