Trial reportClinical oral investigations2014
Effect of a chitosan additive to a Sn2+-containing toothpaste on its anti-erosive/anti-abrasive efficacy--a controlled randomised in situ trial.
Trial report in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Chitosan Use in Dentistry: A Systematic Review of Recent Clinical Studies.Marine drugs · 2019Pooled it
- Preventive effect of chitosan gel containing CaneCPI-5 against enamel erosive wear in situ.Clinical oral investigations · 2022Trial
- Efficacy of a Stannous-containing Dentifrice for Protecting Against Combined Erosive and Abrasive Tooth Wear In Situ.Oral health & preventive dentistry · 2020Trial
- Randomized in situ study on the efficacy of COClinical oral investigations · 2019Trial
- Dental erosion and erosive tooth wear in childhood and adolescence: from diagnosis to prevention.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Review
- Influence of Slurry Diluents on Toothpaste Efficacy Against Erosive Tooth Wear: In Vitro and In Situ Studies.Brazilian dental journal · 2025Article
- Effect of the β-tricalcium phosphate particle on dental enamel associated with 10% carbamide peroxide bleaching.Journal of clinical and experimental dentistry · 2024Article
- Effects of Chitosan as a Novel Obturation Material for Pulpectomized Teeth on Periapical Inflammation, Periodontal Ligament Widening, and Hard Tissue Resorption: A Preliminary Exploratory Study on Dogs.Frontiers in dentistry · 2024Article
- Formulation and antibacterial properties of lollipops containing of chitosan- zinc oxide nano particles on planktonic and biofilm forms of Streptococcus mutans and Lactobacillus acidophilus.BMC oral health · 2023Article
- Impact of combined at-home bleaching and whitening toothpaste use on the surface and color of a composite resin.Restorative dentistry & endodontics · 2023Article
- Chitin and Chitosan as Polymers of the Future-Obtaining, Modification, Life Cycle Assessment and Main Directions of Application.Polymers · 2023Review
- Film-Forming Polymers for Tooth Erosion Prevention.Polymers · 2022Review
- Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- The protective effect of the experimental TiFScientific reports · 2022Article
- The applications of polysaccharides in dentistry.Frontiers in bioengineering and biotechnology · 2022Review
- In situ evaluation of desensitizing toothpastes for protecting against erosive tooth wear and its characterization.Clinical oral investigations · 2021Article
- Polymer-Based Carriers in Dental Local Healing-Review and Future Challenges.Materials (Basel, Switzerland) · 2021Review
- Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro.Scientific reports · 2021Article
- Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation.Nanomaterials (Basel, Switzerland) · 2020Review
- The use of fluoride for the prevention of dental erosion and erosive tooth wear in children and adolescents.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIt is well known that Sn(2+) is a notable anti-erosive agent. There are indications that biopolymers such as chitosan can enhance the effect of Sn(2+), at least in vitro. However, little information exists about their anti-erosive/anti-abrasive in situ effects. In the present in situ study, the efficacy of Sn(2+)-containing toothpastes in the presence or absence of chitosan was tested.
methodsTen subjects participated in the randomised crossover study, wearing mandibular appliances with human enamel specimens. Specimens were extraorally demineralised (7 days, 0.5% citric acid, pH 2.6; 6 × 2 min/day) and intraorally exposed to toothpaste suspensions (2 × 2 min/day). Within the suspension immersion time, one half of the specimens were additionally brushed intraorally with a powered toothbrush (5 s, 2.5 N). Tested preparations were a placebo toothpaste (negative control), two experimental toothpastes (F/Sn = 1,400 ppm F(-), 3,500 ppm Sn(2+); F/Sn/chitosan = 1,400 ppm F(-), 3,500 ppm Sn(2+), 0.5 % chitosan) and an SnF2-containing gel (positive control, GelKam = 3,000 ppm Sn(2+), 1,000 ppm F(-)). Substance loss was quantified profilometrically (μm).
resultsIn the placebo group, tissue loss was 11.2 ± 4.6 (immersion in suspension) and 17.7 ± 4.7 (immersion in suspension + brushing). Immersion in each Sn(2+)-containing suspension significantly reduced tissue loss (p ≤ 0.01); after immersion in suspension + brushing, only the treatments with GelKam (5.4 ± 5.5) and with F/Sn/chitosan (9.6 ± 5.6) significantly reduced loss [both p ≤ 0.05 compared to placebo; F/Sn 12.8 ± 6.4 (not significant)]
conclusionChitosan enhanced the efficacy of the Sn(2+)-containing toothpaste as an anti-erosive/anti-abrasive agent. CLINICAL RELEVANCE: The use of Sn(2+)- and chitosan-containing toothpaste is a good option for symptomatic therapy in patients with regular acid impacts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.