ArticleJournal of bacteriology2013
A Rex family transcriptional repressor influences H2O2 accumulation by Enterococcus faecalis.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Carbon metabolism and niche adaptation inmSphere · 2026Review
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- A conserved sRNA regulates mucin adhesion and gut colonization across the Enterococcaceae.bioRxiv : the preprint server for biology · 2025Article
- The cell wall hydrolase MltG is essential to maintain cell wall homeostasis ofJournal of bacteriology · 2025Article
- The adjacent ATP-binding protein-encoding genes of theJournal of bacteriology · 2025Article
- The extracellular segment of CroS is not required for sensing but fine-tunes the magnitude of CroS signaling to regulate cephalosporin resistance inJournal of bacteriology · 2024Article
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- Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness ofbioRxiv : the preprint server for biology · 2024Article
- PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs.Life science alliance · 2024Article
- Disruption of theJournal of bacteriology · 2022Article
- CroR Regulates Expression ofmBio · 2022Article
- Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation inAntioxidants (Basel, Switzerland) · 2022Article
- Structural Basis of Redox-Sensing Transcriptional Repressor Rex with Cofactor NADInternational journal of molecular sciences · 2022Article
- NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.PLoS pathogens · 2021Article
- How Bacterial Redox Sensors Transmit Redox Signals via Structural Changes.Antioxidants (Basel, Switzerland) · 2021Review
- Single-Cell Analysis Reveals that the Enterococcal Sex Pheromone Response Results in Expression of Full-Length Conjugation Operon Transcripts in All Induced Cells.Journal of bacteriology · 2020Article
- Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci.Antimicrobial agents and chemotherapy · 2020Article
- Single-Nucleotide RNA Maps for the Two Major Nosocomial PathogensFrontiers in cellular and infection microbiology · 2020Article
- TheFrontiers in microbiology · 2020Article
- Role ofJournal of bacteriology · 2019Article
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Authors and funding
2 authors.
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Abstract
Rex factors are bacterial transcription factors thought to respond to the cellular NAD(+)/NADH ratio in order to modulate gene expression by differentially binding DNA. To date, Rex factors have been implicated in regulating genes of central metabolism, oxidative stress response, and biofilm formation. The genome of Enterococcus faecalis, a low-GC Gram-positive opportunistic pathogen, encodes EF2638, a putative Rex factor. To study the role of E. faecalis Rex, we purified EF2638 and evaluated its DNA binding activity in vitro. EF2638 was able to bind putative promoter segments of several E. faecalis genes in an NADH-responsive manner, indicating that it represents an authentic Rex factor. Transcriptome analysis of a ΔEF2638 mutant revealed that genes likely to be involved in anaerobic metabolism were upregulated during aerobic growth, and the mutant exhibited an altered NAD(+)/NADH ratio. The ΔEF2638 mutant also exhibited a growth defect when grown with aeration on several carbon sources, suggesting an impaired ability to cope with oxidative stress. Inclusion of catalase in the medium alleviated the growth defect. H(2)O(2) measurements revealed that the mutant accumulates significantly more H(2)O(2) than wild-type E. faecalis. In summary, EF2638 represents an authentic Rex factor in E. faecalis that influences the production or detoxification of H(2)O(2) in addition to its more familiar role as a regulator of anaerobic gene expression.
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