ReviewEnvironmental science and pollution research international2014
Influence of nutrition in PCB-induced vascular inflammation.
Review in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Association of polychlorinated biphenyls with vitamin D among rural Chinese adults with normal glycaemia and type 2 diabetes mellitus.Environmental health : a global access science source · 2024Article
- PCB126 exposure during pregnancy alters maternal and fetal gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
- Potential benefits of joint hypothetical interventions on diet, lead, and cadmium on mortality in US adults.Environmental health : a global access science source · 2022Article
- Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids.International journal of molecular sciences · 2022Review
- Tomato and Olive Bioactive Compounds: A Natural Shield against the Cellular Effects Induced by β-Hexachlorocyclohexane-Activated Signaling Pathways.Molecules (Basel, Switzerland) · 2021Article
- Micronutrient-rich dietary intake is associated with a reduction in the effects of particulate matter on blood pressure among electronic waste recyclers at Agbogbloshie, Ghana.BMC public health · 2020Article
- Article
- Diabetes and Toxicant Exposure.Integrative medicine (Encinitas, Calif.) · 2020Review
- Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons.Journal of family medicine and primary care · 2019Article
- Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- The role of nutrition in influencing mechanisms involved in environmentally mediated diseases.Reviews on environmental health · 2018Review
- Fish Oil Contaminated with Persistent Organic Pollutants Induces Colonic Aberrant Crypt Foci Formation and Reduces Antioxidant Enzyme Gene Expression in Rats.The Journal of nutrition · 2017Article
- Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications.Environmental science and pollution research international · 2017Article
- Impact of nutrition on pollutant toxicity: an update with new insights into epigenetic regulation.Reviews on environmental health · 2017Review
- Therapeutic properties of green tea against environmental insults.The Journal of nutritional biochemistry · 2017Review
- Effects of the Dietary Detoxification Program on SerumJournal of lifestyle medicine · 2016Article
- Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors.The Journal of nutritional biochemistry · 2016Article
- Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis.International journal of molecular sciences · 2016Review
- Polychlorinated biphenyls and links to cardiovascular disease.Environmental science and pollution research international · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The nutritional profile of an individual can influence the toxicity of persistent environmental toxicants. Polychlorinated biphenyls (PCBs), prevalent environmental pollutants, are highly lipid-soluble toxic compounds that biomagnify through trophic levels and pose cancer, neurocognitive, and atherosclerotic risk to human populations. There is a growing body of knowledge that PCBs can initiate inflammatory responses in vivo, and this inflammation can be either exacerbated or ameliorated by nutrition. Data indicate that diets high in certain dietary lipids such as omega-6 fatty acids can worsen PCB-induced vascular toxicity while diets enriched with bioactive food components such as polyphenols and omega-3 polyunsaturated fatty acids can improve the toxicant-induced inflammation. There is evidence that bioactive nutrients protect through multiple cell signaling pathways, but we have shown that lipid raft caveolae and the antioxidant defense controller nuclear factor (erythroid-derived 2)-like 2 (Nrf2) both play a predominant role in nutritional modulation of PCB-induced vascular toxicity. Interestingly, there appears to be an intimate cross-talk between caveolae-related proteins and cellular Nrf2, and focusing on the use of specific bioactive food components that simultaneously alter both pathways may produce a more effective and efficient cytoprotective response to toxicant exposure. The use of nutrition as a protective tool is an economically beneficial means to address the toxicity of persistent environmental toxicants and may become a sensible means to protect human populations from PCB-induced vascular inflammation and associated chronic diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.