ArticleJapanese journal of ophthalmology2013
Positive correlation between the degree of visual field defect and optic radiation damage in glaucoma patients.
Article in Japanese journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02570867 (Study on the Changes of Brain Function in Primary Open-angle Glaucoma Patients With fMRI), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Changes of Brain Function in Primary Open-angle Glaucoma Patients With fMRI
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Neurodegeneration in Glaucoma: Microstructural Magnetic Resonance Imaging Evidence Within and Beyond the Visual Pathway.Investigative ophthalmology & visual science · 2026Article
- Low-Cost and Detunable Wireless Resonator Glasses for Enhanced Eye MRI With Concurrent High-Quality Whole-Brain MRI.Magnetic resonance in medicine · 2026Article
- Article
- Application of diffusion tensor imaging technology in glaucoma diagnosis.Frontiers in neuroscience · 2023Review
- Microstructural Visual Pathway White Matter Alterations in Primary Open-Angle Glaucoma: A Neurite Orientation Dispersion and Density Imaging Study.AJNR. American journal of neuroradiology · 2022Article
- Sensory integration abilities for balance in glaucoma, a preliminary study.Scientific reports · 2021Article
- White matter alterations in glaucoma and monocular blindness differ outside the visual system.Scientific reports · 2021Article
- Progression of Visual Pathway Degeneration in Primary Open-Angle Glaucoma: A Longitudinal Study.Frontiers in human neuroscience · 2021Article
- The development of white matter structural changes during the process of deterioration of the visual field.Scientific reports · 2019Article
- Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage.NeuroImage. Clinical · 2019Article
- [Diffusion tensor imaging of the visual pathway in glaucomatous optic nerve atrophy].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Review
- Early changes of brain connectivity in primary open angle glaucoma.Human brain mapping · 2016Article
- Using magnetic resonance imaging to assess visual deficits: a review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2016Review
- White matter consequences of retinal receptor and ganglion cell damage.Investigative ophthalmology & visual science · 2014Article
- Structural and functional brain changes beyond visual system in patients with advanced glaucoma.PloS one · 2014Article
- Altered white matter integrity in the congenital and late blind people.Neural plasticity · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated optic radiation (OR) damage in patients with glaucoma by using fractional anisotropy (FA) of diffusion-tensor magnetic resonance imaging.
methodsWe studied 29 patients with glaucoma and 19 healthy controls. Regions of interest were placed over the bilateral anterior and posterior ORs on the FA maps, and the FA value of each region was measured.
resultsFA values of the bilateral anterior and posterior ORs were significantly lower in patients with glaucoma (anterior right, P = 0.0002; anterior left, P = 0.00028; posterior right, P = 0.0004; and posterior left, P = 0.0001) than in the healthy controls. In glaucoma patients, significant correlations were observed between the FA values and the average of the total deviation of the contralateral hemifields of both eyes (left hemifield and anterior right OR, correlation coefficient [r] = 0.46 [P = 0.013]; right hemifield and anterior left OR, r = 0.43 [P = 0.021]; left hemifield and posterior right OR, r = 0.54 [P = 0.0027]; and right hemifield and posterior left OR, r = 0.46 [P = 0.012]).
conclusionsFA values of the entire OR were decreased in glaucoma patients and correlated with the degree of visual field defect.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.