ArticleImmunogenetics2013
Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Mergers and migrations: drivers of population genetic structure in a captive rhesus macaque colony.BMC genomics · 2026Article
- A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys.Arthritis research & therapy · 2022Article
- A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques.Vaccines · 2021Article
- Evidence of a tolerogenic vaccine against AIDS in the Chinese macaque prefigures a potential human vaccine.Archives of virology · 2021Review
- The HLA A03 Supertype and SeveralJournal of virology · 2020Article
- Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations.PLoS biology · 2019Article
- A 30-year journey of trial and error towards a tolerogenic AIDS vaccine.Archives of virology · 2018Review
- Article
- Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques.Chinese medicine · 2016Article
- The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans.Tuberculosis (Edinburgh, Scotland) · 2015Article
- Co-evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity.Immunological reviews · 2015Review
- A population response analysis approach to assign class II HLA-epitope restrictions.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation.Scientific reports · 2015Article
- HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques.Immunogenetics · 2013Article
- Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates.Current opinion in HIV and AIDS · 2013Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Chinese rhesus macaques are of particular interest in simian immunodeficiency virus/human immunodeficiency virus (SIV/HIV) research as these animals have prolonged kinetics of disease progression to acquired immunodeficiency syndrome (AIDS), compared to their Indian counterparts, suggesting that they may be a better model for HIV. Nevertheless, the specific mechanism(s) accounting for these kinetics remains unclear. The study of major histocompatibility complex (MHC) molecules, including their MHC/peptide-binding motifs, provides valuable information for measuring cellular immune responses and deciphering outcomes of infection and vaccine efficacy. In this study, we have provided detailed characterization of six prevalent Chinese rhesus macaque MHC class I alleles, yielding a combined phenotypic frequency of 29 %. The peptide-binding specificity of two of these alleles, Mamu-A2*01:02 and Mamu-B*010:01, as well as the previously characterized allele Mamu-B*003:01 (and Indian rhesus Mamu-B*003:01), was found to be analogous to that of alleles in the HLA-B27 supertype family. Specific alleles in the HLA-B27 supertype family, including HLA-B*27:05, have been associated with long-term nonprogression to AIDS in humans. All six alleles characterized in the present study were found to have specificities analogous to HLA supertype alleles. These data contribute to the concept that Chinese rhesus macaque MHC immunogenetics is more similar to HLA than their Indian rhesus macaque counterparts and thereby warrants further studies to decipher the role of these alleles in the context of SIV infection.
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