ArticleApplied and environmental microbiology2013
Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification ofVirulence · 2021Pooled it
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- Developing a cps-genotyping scheme for the emerging zoonotic pathogen Streptococcus parasuis through genetic analysis of capsular polysaccharide synthesis gene loci.BMC microbiology · 2026Article
- Macrolide resistance determinants and their associations in streptococci from selected livestock and wildlife species from Catalonia, Northeast Spain.Microbiology spectrum · 2026Article
- Serovar-Dependent Gene Regulation and Antimicrobial Tolerance inAntibiotics (Basel, Switzerland) · 2025Article
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- Tyrosine kinase Cps2C regulates the synthesis of capsular polysaccharides and plays a role in the virulence ofVirulence · 2025Article
- Genomic analysis and virulence of human Streptococcus suis serotype 14.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Comparative genomic analysis of Streptococcus suis sequence type 105 and development of a PCR diagnostic tool.PloS one · 2025Article
- Whole genome sequence and characterisation of Streptococcus suis 3112, isolated from snakeskin gourami, Trichopodus pectoralis.BMC genomics · 2024Article
- Virulence genes, resistome and mobilome ofMicrobial genomics · 2024Article
- Characterization of pig tonsils as niches for the generation of Streptococcus suis diversity.Veterinary research · 2024Article
- Genome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer.BMC genomics · 2024Article
- The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.Scientific reports · 2023Article
- New Characterization of Multi-Drug Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Population structure and genetic diversity ofFrontiers in microbiology · 2023Article
- A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness.PLoS pathogens · 2022Article
- Genomic and pathogenic investigations ofEmerging microbes & infections · 2021Article
3 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis strains are classified into 35 serotypes on the basis of the antigenicity of their capsular polysaccharides (CPs). CP synthesis genes are known to be clustered on the chromosome (cps gene cluster). The entire cps gene clusters of S. suis have so far been sequenced in 15 serotypes and found to be located between orfZ and aroA. In this study, to provide comprehensive information about S. suis CPs, we sequenced the entire cps gene clusters of the remaining serotypes and analyzed the complete set of S. suis cps gene clusters. Among the 35 cps gene clusters, 22 were located between orfZ and aroA, whereas the other 13 were flanked by other gene(s) on the chromosomes, and the chromosomal locus was classified into five patterns. By clustering analysis, the predicted products of cps genes found in the 35 serotypes were assigned into 291 homology groups, and all serotypes possessed a serotype-specific gene, except for serotypes 1, 2, 1/2, and 14. Because of the presence of genes encoding flippase (wzx) and polymerase (wzy), CPs of all serotypes were thought to be synthesized by the Wzx/Wzy pathway. Our data also implied the possibility of the transfer of the entire or partial cps gene clusters among S. suis strains, as well as the influence of spontaneous mutations in a single gene or a few genes on the antigenicity of some serotypes. Accumulation of these gene transfers and small-scale mutations may have generated the antigenic diversity of S. suis CPs.
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