Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Conditioned preference to a methamphetamine-associated contextual cue in humans.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust.Journal of psychopharmacology (Oxford, England) · 2026Trial
- Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice.Nature communications · 2026Article
- Place conditioning in humans: opportunities for translational research.Psychopharmacology · 2023Article
- Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations.Scientific reports · 2023Article
- Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.Neuroscience and biobehavioral reviews · 2022Review
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
- Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration.Psychopharmacology · 2021Article
- Effects of Methamphetamine on Within- and Between-Network Connectivity in Healthy Adults.Cerebral cortex communications · 2021Article
- Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.Addiction biology · 2020Article
- Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans.Psychopharmacology · 2019Article
- Genome wide association analysis in a mouse advanced intercross line.Nature communications · 2018Article
- Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks.Psychopharmacology · 2018Article
- The hot 'n' cold of cue-induced drug relapse.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Neural responses to cues paired with methamphetamine in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving.JAMA psychiatry · 2017Article
- Extinction of Conditioned Responses to Methamphetamine-Associated Stimuli in Healthy Humans.Psychopharmacology · 2016Article
- Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers.Journal of studies on alcohol and drugs · 2016Article
- Androgen-primed castrate males are sufficient for methamphetamine-facilitated increases in proceptive behavior in female rats.Hormones and behavior · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans. We established a procedure suitable for studying the neurobiology and individual determinants of classical conditioning in humans. Healthy volunteers were randomly assigned to four groups that received methamphetamine or placebo in the presence of distinctive environmental cues under paired or unpaired conditions. During each session, subjects performed tasks known to activate the ventral striatum. Tasks were performed in the presence of a distinctive context, consisting of a screen background image of a beach or mountains, accompanied by corresponding sounds. Separate groups of subjects carried out the tasks under high ($35-50) or low ($5-20) reward conditions. Within each of the two reward conditions, one group (paired) received methamphetamine (20 mg, oral) or placebo consistently associated with one of the contexts, while the other (unpaired) received drug or placebo unrelated to context. A fifth group (paired) performed the tasks with contextual cues but in the absence of monetary incentives. Before and after conditioning, participants carried out a series of forced choice tasks for the contextual cues, and change of preference over time was analyzed. All paired groups showed a significant increase in preference for the drug-associated context, with a linear trend for increase across the levels of reward. Preference was unrelated to subjective drug effects, and did not change in the unpaired group. These data support the translational utility of our conditioning procedure for studies of reward mechanisms in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.