ReviewBone2013
A review of mouse critical size defect models in weight bearing bones.
Review in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Cerclage Wire as an Affordable Alternative for Internal Fixation in Murine Critical Sized Defect Models.bioRxiv : the preprint server for biology · 2026Article
- Standardized Photobiomodulation Dosimetry Targeting the Base of Calvarial Critical-Sized Defects for Bone Regeneration: A Preclinical RCT Comparing Flattop vs. Gaussian Beam Profiles, with or Without Bio-OssJournal of functional biomaterials · 2026Article
- 3D-Printed Titanium Implants with Bioactive Peptide-Polysaccharide Scaffolds for Personalized Bone Reconstruction.Advanced healthcare materials · 2026Article
- Comprehensive evaluation of critical-size calvarial defect in athymic rat model.Frontiers in physiology · 2025Article
- EMF treatment delays mesenchymal stem cells senescence during long-termFrontiers in cell and developmental biology · 2024Article
- The specialist in regeneration-the Axolotl-a suitable model to study bone healing?NPJ Regenerative medicine · 2022Article
- Recent Research on Hybrid Hydrogels for Infection Treatment and Bone Repair.Gels (Basel, Switzerland) · 2022Review
- Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2021Review
- Microarchitecture of titanium cylinders obtained by additive manufacturing does not influence osseointegration in the sheep.Regenerative biomaterials · 2021Article
- Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography.Scientific reports · 2021Article
- Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors.Communications biology · 2021Article
- Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.Scientific reports · 2021Article
- Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models.Archives of toxicology · 2020Review
- Effects of electromagnetic fields treatment on rat critical-sized calvarial defects with a 3D-printed composite scaffold.Stem cell research & therapy · 2020Article
- Review
- Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.Tissue engineering and regenerative medicine · 2019Article
- Vascularized Periosteal Flaps Accelerate Osteointegration and Revascularization of Allografts in Rats.Clinical orthopaedics and related research · 2019Article
- Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model.Nanomaterials (Basel, Switzerland) · 2018Review
- Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats.Journal of dentistry (Tehran, Iran) · 2018Article
- Proposal of a Novel Natural Biomaterial, the Scleral Ossicle, for the Development of Vascularized Bone Tissue In Vitro.Biomedicines · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Current and future advances in orthopedic treatment are aimed at altering biological interactions to enhance bone healing. Currently, several clinical scenarios exist for which there is no definitive treatment, specifically segmental bone loss from high-energy trauma or surgical resection - and it is here that many are aiming to find effective solutions. To test experimental interventions and better understand bone healing, researchers employ critical size defect (CSD) models in animal studies. Here, an overview of CSDs is given that includes the specifications of varying models, a discussion of current scaffold and bone graft designs, and current outcome measures used to determine the extent of bone healing. Many promising graft designs have been discovered along with promising adjunctive treatments, yet a graft that offers biomechanical support while allowing for neovascularization with eventual complete resorption and remodeling remains to be developed. An overview of this important topic is needed to highlight current advances and provide a clear understanding of the ultimate goal in CSD research--develop a graft for clinical use that effectively treats the orthopedic conundrum of segmental bone loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.