ArticleNature methods2013
Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation.
Article in Nature methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 91 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed.
- Single-phage profiling illuminates viral individuality during bacterial cell fate determination.Nature communications · 2026Article
- Modern RNA Quantification Methods: From RT-qPCR to Advanced Microscopy.The journal of physical chemistry. B · 2026Review
- Single-phage profiling illuminates viral individuality during cell fate determination.bioRxiv : the preprint server for biology · 2026Article
- Highly Multiplexed Single-Cell In Situ RNA and DNA Analysis by Consecutive Hybridization.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- Activation-derepression synergy enables a bHLH network to coordinate a signal-specific fate response.Cell reports · 2024Article
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- Dissecting the brain with spatially resolved multi-omics.Journal of pharmaceutical analysis · 2023Review
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- Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks.Cell systems · 2022Article
- Spatial omics technologies at multimodal and single cell/subcellular level.Genome biology · 2022Review
- The emerging landscape of spatial profiling technologies.Nature reviews. Genetics · 2022Review
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- Inferring gene regulation from stochastic transcriptional variation across single cells at steady state.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- In Situ Imaging of mRNA Splicing Variants by SpliceRCA.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Improved Methods for Single-Molecule Fluorescence In Situ Hybridization and Immunofluorescence in Caenorhabditis elegans Embryos.Current protocols · 2021Article
- PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency.Nature structural & molecular biology · 2021Article
- Highly Sensitive and Multiplexed In Situ RNA Profiling with Cleavable Fluorescent Tyramide.Cells · 2021Article
- Determination of complete chromosomal haplotypes by bulk DNA sequencing.Genome biology · 2021Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
We report intron chromosomal expression FISH (iceFISH), a multiplex imaging method for measuring gene expression and chromosome structure simultaneously on single chromosomes. We find substantial differences in transcriptional frequency between genes on a translocated chromosome and the same genes in their normal chromosomal context in the same cell. Correlations between genes on a single chromosome pointed toward a cis chromosome-level transcriptional interaction spanning 14.3 megabases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.