ArticleNature materials2013
High-resolution three-photon biomedical imaging using doped ZnS nanocrystals.
Article in Nature materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
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- High-Performance PbSe Quantum Dots with Palmitoyl Chloride and Their Application to Short-Wavelength Infrared Photodetector Devices.Small methods · 2025Article
- Unlocking multi-photon excited luminescence in pyrazolate trinuclear gold clusters for dynamic cell imaging.Nature communications · 2024Article
- Simultaneous 3D Construction and Imaging of Plant Cells Using Plasmonic Nanoprobe-Assisted Multimodal Nonlinear Optical Microscopy.Nanomaterials (Basel, Switzerland) · 2023Article
- Durable organic nonlinear optical membranes for thermotolerant lightings and in vivo bioimaging.Nature communications · 2023Article
- Multiphoton excited singlet/triplet mixed self-trapped exciton emission.Nature communications · 2023Article
- MnNature communications · 2022Article
- Improved One- and Multiple-Photon Excited Photoluminescence from CdNanomaterials (Basel, Switzerland) · 2022Article
- In situ NMR reveals real-time nanocrystal growth evolution via monomer-attachment or particle-coalescence.Nature communications · 2021Article
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- Emergence of Impurity-Doped Nanocrystal Light-Emitting Diodes.Nanomaterials (Basel, Switzerland) · 2020Review
- Miniaturized multimodal multiphoton microscope for simultaneous two-photon and three-photon imaging with a dual-wavelength Er-doped fiber laser.Biomedical optics express · 2020Article
- A Deep Ultraviolet Mode-locked Laser Based on a Neural Network.Scientific reports · 2020Article
- Lanthanide-Doped Upconversion Nanoparticles for Super-Resolution Microscopy.Frontiers in chemistry · 2020Article
- FeSe quantum dots for in vivo multiphoton biomedical imaging.Science advances · 2019Article
- Long-lived Photon Upconversion Phosphorescence in RbCaFiScience · 2019Article
- Inorganic semiconductor biointerfaces.Nature reviews. Materials · 2018Article
- Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2018Article
- Recent Development of Inorganic Nanoparticles for Biomedical Imaging.ACS central science · 2018Review
- Nonlinear Absorption Response Correlated to Embedded Ag Nanoparticles in BGO Single Crystal: From Two-Photon to Three-Photon Absorption.Scientific reports · 2018Article
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn(2+) dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging.
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