Evidence map›Paper›PMID 23416678›Full record

ReviewNature immunology2013

MicroRNAs as mediators of viral evasion of the immune system.

Bryan R Cullen

Abstract readReview
In one paragraph

Review in Nature immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed.

  1. High uPAR and Low miR-221 Expression Predict Poor Disease-Free Survival in Triple-Negative Breast Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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  10. AcMNPV-miR-2 affectsJournal of virology · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Shaping the host cell environment with viral noncoding RNAs.Seminars in cell & developmental biology · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bryan R CullenDepartment of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina, USA. bryan.cullen@duke.edu

Funding

Role and mechanism of action of Gamma herpesvirus microRNAsR01AI067968 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2006 to 2016
$3.6M
HIV-1: microRNA interactionsR01DA030086 · NIDA · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2010 to 2014
$1.9M
Regulation of lytic and latent infection by HSV-1 encoded miRNAsR01AI097376 · NIAID · UNIVERSITY OF FLORIDA · PI BLOOM, DAVID C. · 2012 to 2016
$1.9M
Influenza virus small RNAsR21AI088327 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2010 to 2011
$427k
NIAID NIH HHS R01 AI067968NIAID NIH HHS R01-AI067968NIAID NIH HHS R01-AI0973376NIAID NIH HHS R01 AI097376NIAID NIH HHS R21 AI088327NIDA NIH HHS R01 DA030086NIDA NIH HHS R01-DA030086
6 · The paper itself

Abstract

Cellular microRNAs serve key roles in the post-transcriptional regulation of almost every cellular gene-regulatory pathway, and it therefore is not surprising that viruses have found ways to subvert this process. Several viruses encode microRNAs that directly downregulate the expression of factors of the innate immune system, including proteins involved in promoting apoptosis and recruiting effector cells of the immune system. Viruses have also evolved the ability to downregulate or upregulate the expression of specific cellular miRNAs to enhance their replication. This Review provides an overview of the present knowledge of the complex interactions of viruses with the microRNA machinery of cells.

Indexed as

VirusesAnimalsApoptosisCytokinesGene Expression RegulationHumansImmune EvasionMicroRNAsRNA, ViralVirus ReplicationCytokinesMicroRNAsRNA, Viral

Identifiers

PMID23416678
PMCPMC3642974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.