ArticleActa biomaterialia2013
Semi-interpenetrating network (sIPN) gelatin nanofiber scaffolds for oral mucosal drug delivery.
Article in Acta biomaterialia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial.Inflammopharmacology · 2023Trial
- Biomedical applications of stimuli-responsive "smart" interpenetrating polymer network hydrogels.Materials today. Bio · 2024Review
- Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers.Biomolecules · 2022Review
- Current Understanding of the Applications of Photocrosslinked Hydrogels in Biomedical Engineering.Gels (Basel, Switzerland) · 2022Review
- Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives.International journal of molecular sciences · 2021Review
- Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine.Pharmaceutics · 2020Review
- New Oral Coaxial Nanofibers for Gadodiamide-Prospective Intestinal Magnetic Resonance Imaging and Theranostic.International journal of nanomedicine · 2020Article
- Electrospinning of Fish Gelatin Solution Containing Citric Acid: An Environmentally Friendly Approach to Prepare Crosslinked Gelatin Fibers.Materials (Basel, Switzerland) · 2019Article
- Large-Scale and Rapid Preparation of Nanofibrous Meshes and Their Application for Drug-Loaded Multilayer Mucoadhesive Patch Fabrication for Mouth Ulcer Treatment.ACS applied materials & interfaces · 2019Article
- Polycaprolactone nanofibres loaded with 20(Royal Society open science · 2018Article
- Chitosan nanofibers for transbuccal insulin delivery.Journal of biomedical materials research. Part A · 2017Article
- Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis.International journal of nanomedicine · 2017Article
- Electrospinning of PEGylated polyamidoamine dendrimer fibers.Materials science & engineering. C, Materials for biological applications · 2015Article
- The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application.Biomaterials science · 2015Article
- Semi-interpenetrating network (sIPN) co-electrospun gelatin/insulin fiber formulation for transbuccal insulin delivery.Pharmaceutical research · 2015Article
- 2,3-Dihydroxybenzoic acid electrospun into poly(D,L-lactide) (PDLLA)/poly(ethylene oxide) (PEO) nanofibers inhibited the growth of Gram-positive and Gram-negative bacteria.Current microbiology · 2014Article
- Biological effects of Spirulina (Arthrospira) biopolymers and biomass in the development of nanostructured scaffolds.BioMed research international · 2014Review
- Electrospun blends of gelatin and gelatin-dendrimer conjugates as a wound-dressing and drug-delivery platform.Biomacromolecules · 2013Article
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Authors and funding
6 authors.
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Abstract
The oral mucosa is a promising absorption site for drug administration because it is permeable, highly vascularized and allows for ease of administration. Nanofiber scaffolds for local or systemic drug delivery through the oral mucosa, however, have not been fully explored. In this work, we fabricated electrospun gelatin nanofiber scaffolds for oral mucosal drug delivery. To improve structural stability of the electrospun gelatin scaffolds and allow non-invasive incorporation of therapeutics into the scaffold, we employed photo-reactive polyethylene glycol diacrylate (PEG-DA575, 575 gmol(-1)) as a cross-linker to stabilize the scaffold by forming semi-interpenetrating network gelatin nanofiber scaffolds (sIPN NSs), during which cross-linker concentration was varied (1×, 2×, 4× and 8×). The results showed that electrospun gelatin nanofiber scaffolds after being cross-linked with PEG-DA575 (i.e. sIPN NS1×, 2×, 4× and 8×) retained fiber morphology and possessed improved structural stability. A series of structural parameters and properties of the cross-linked electrospun gelatin scaffolds were systematically characterized in terms of morphology, fiber diameter, mechanical properties, porosity, swelling and degradation. Mucin absorption onto sIPN NS4× was also confirmed, indicating this scaffold possessed greatest mucoadhesion properties among those tested. Slow release of nystatin, an anti-fungal reagent, from the sIPN gelatin nanofiber scaffold was demonstrated.
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