ReviewAgeing research reviews2013
Food for thought: the role of appetitive peptides in age-related cognitive decline.
Review in Ageing research reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Trial
- Article
- Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?Antioxidants (Basel, Switzerland) · 2025Review
- Differential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Orexin/Hypocretin Modulates Neuroinflammatory Response to LPS in a Sex and Brain-Region Specific Manner in Young Rats.Journal of neurochemistry · 2025Article
- Obesity reduces hippocampal structure and function in older African Americans with the APOE-ε4 Alzheimer's disease risk allele.Frontiers in aging neuroscience · 2023Article
- Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review.Nutrients · 2022Review
- High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice.Nutrition & metabolism · 2022Article
- Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.Journal of medicinal chemistry · 2021Article
- Intranasal insulin and orexins to treat age-related cognitive decline.Physiology & behavior · 2021Review
- Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions.Brain sciences · 2020Review
- Orexin and Alzheimer's Disease: A New Perspective.Psychiatry investigation · 2020Article
- Maternal stressors and the developmental origins of neuropsychiatric risk.Frontiers in neuroendocrinology · 2020Review
- Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition.Brain plasticity (Amsterdam, Netherlands) · 2019Article
- Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring.Experimental neurology · 2019Article
- Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.Scientific reports · 2019Observational
- Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus.Frontiers in molecular neuroscience · 2019Review
- Associations of cord blood leptin and adiponectin with children's cognitive abilities.Psychoneuroendocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Through their well described actions in the hypothalamus, appetitive peptides such as insulin, orexin and leptin are recognized as important regulators of food intake, body weight and body composition. Beyond these metabolic activities, these peptides also are critically involved in a wide variety of activities ranging from modulation of immune and neuroendocrine function to addictive behaviors and reproduction. The neurological activities of insulin, orexin and leptin also include facilitation of hippocampal synaptic plasticity and enhancement of cognitive performance. While patients with metabolic disorders such as obesity and diabetes have greater risk of developing cognitive deficits, dementia and Alzheimer's disease (AD), the underlying mechanisms that are responsible for, or contribute to, age-related cognitive decline are poorly understood. In view of the importance of these peptides in metabolic disorders, it is not surprising that there is a greater focus on their potential role in cognitive deficits associated with aging. The goal of this review is to describe the evidence from clinical and pre-clinical studies implicating insulin, orexin and leptin in the etiology and progression of age-related cognitive decline. Collectively, these studies support the hypothesis that leptin and insulin resistance, concepts normally associated with the hypothalamus, are also applicable to the hippocampus.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.