Trial reportBrain, behavior, and immunity2013
Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?
Trial report in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference.Brain, behavior, and immunity · 2022Trial
- The Dangerous Liaison Between Depression and Cardiovascular Disease: A Narrative Review of Epidemiology, Mechanisms, and Clinical Management.Journal of clinical medicine · 2026Review
- Neurovascular interactions in the ageing heart.Nature reviews. Cardiology · 2026Review
- Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- Posttraumatic stress disorder, depressive and cardiovascular disease symptoms among young patients receiving medical treatment in a heart centre: A cross-sectional study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2024Article
- Role of stress and early-life stress in the pathogeny of inflammatory bowel disease.Frontiers in neuroscience · 2024Review
- Heart Rate Variability as a Translational Dynamic Biomarker of Altered Autonomic Function in Health and Psychiatric Disease.Biomedicines · 2023Review
- Heart rate variability during slow wave sleep is linked to functional connectivity in the central autonomic network.Brain communications · 2023Article
- The omnipresence of autonomic modulation in health and disease.Progress in neurobiology · 2022Review
- Takotsubo Syndrome: Translational Implications and Pathomechanisms.International journal of molecular sciences · 2022Review
- Structural and functional connections between the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and the immune system: a context and time dependent stress response network.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine.Frontiers in cardiovascular medicine · 2021Review
- Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder.Translational psychiatry · 2020Review
- Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.Molecular psychiatry · 2020Article
- Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease.Psychosomatic medicine · 2020Article
- Cardiovascular reactivity to acute stress associated with sickness absence among Japanese men and women: A prospective study.Brain and behavior · 2020Article
- Using heart rate profiles during sleep as a biomarker of depression.BMC psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation is a risk factor for both depression and cardiovascular disease. Depressed mood is also a cardiovascular risk factor. To date, research into mechanisms through which inflammation impacts cardiovascular health rarely takes into account central effects on autonomic cardiovascular control, instead emphasizing direct effects of peripheral inflammatory responses on endothelial reactivity and myocardial function. However, brain responses to inflammation engage neural systems for motivational and homeostatic control and are expressed through depressed mood state and changes in autonomic cardiovascular regulation. Here we combined an inflammatory challenge, known to evoke an acute reduction in mood, with neuroimaging to identify the functional brain substrates underlying potentially detrimental changes in autonomic cardiovascular control. We first demonstrated that alterations in the balance of low to high frequency (LF/HF) changes in heart rate variability (a measure of baroreflex sensitivity) could account for some of the inflammation-evoked changes in diastolic blood pressure, indicating a central (rather than solely local endothelial) origin. Accompanying alterations in regional brain metabolism (measured using (18)FDG-PET) were analysed to localise central mechanisms of inflammation-induced changes in cardiovascular state: three discrete regions previously implicated in stressor-evoked blood pressure reactivity, the dorsal anterior and posterior cingulate and pons, strongly mediated the relationship between inflammation and blood pressure. Moreover, activity changes within each region predicted the inflammation-induced shift in LF/HF balance. These data are consistent with a centrally-driven component originating within brain areas supporting stressor evoked blood pressure reactivity. Together our findings highlight mechanisms binding psychological and physiological well-being and their perturbation by peripheral inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.