Evidence map›Paper›PMID 23415831›Full record

ArticleCurrent opinion in neurobiology2013

Addiction: a drug-induced disorder of memory reconsolidation.

Natalie C Tronson, Jane R Taylor

Abstract read
In one paragraph

Article in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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  14. Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Natalie C TronsonDepartment of Psychology, University of Michigan, Ann Arbor, MI 48109, USA. ntronson@umich.edu
Jane R Taylor

Funding

Incentive Motivation in Addiction: PKA MechanismsR01DA015222 · NIDA · YALE UNIVERSITY · PI TAYLOR, JANE R · 2003 to 2013
$2.7M
Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial InfarctionR00MH093459 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRONSON, NATALIE CELIA · 2012 to 2014
$736k
Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial InfarctionK99MH093459 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TRONSON, NATALIE CELIA · 2011 to 2012
$176k
NIDA NIH HHS DA015222NIDA NIH HHS R01 DA015222NIMH NIH HHS K99 MH093459NIMH NIH HHS MH093459NIMH NIH HHS R00 MH093459
6 · The paper itself

Abstract

Persistent maladaptive memories that maintain drug seeking and are resistant to extinction are a hallmark of addiction. As such, disruption of memory reconsolidation after retrieval has received attention for its therapeutic potential. Unrestrained reconsolidation may have the opposite effect, leading to reiterative and cumulative strengthening of memory over long periods of time. Here we review the molecular mechanisms underlying reconsolidation of appetitive and drug-rewarded memories, and discuss how these findings contribute to our understanding of the nature of this process. Finally, we suggest that drug-induced alterations to signal transduction might lead to dysregulation of reconsolidation, causing enhancements of drug-related memory after retrieval, and significantly contribute to the compulsive drug seeking that is a core component of addiction.

Indexed as

AnimalsHumansIllicit DrugsMemory DisordersRewardSignal TransductionSubstance-Related DisordersIllicit Drugs

Identifiers

PMID23415831
PMCPMC3677957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.