Evidence map›Paper›PMID 23415801›Full record

ReviewGastroenterology2013

Pathology of rodent models of intestinal cancer: progress report and recommendations.

Mary Kay Washington, Anne E Powell, Ruth Sullivan, John P Sundberg, Nicholas Wright, Robert J Coffey, William F Dove

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  16. YYFZBJS ameliorates colorectal cancer progression in ApcCell communication and signaling : CCS · 2020
    Article
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  18. Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Mary Kay WashingtonDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Anne E Powell
Ruth Sullivan
John P Sundberg
Nicholas Wright
Robert J Coffey
William F Dove
Vanderbilt University Medical Center · USBarts Health NHS Trust · GBJackson Laboratory · USUniversity of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin–Madison · USVeterans Health Administration · US

Funding

Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Mouse Models of Human Cancer DatabaseR01CA089713 · NCI · JACKSON LABORATORY · PI BULT, CAROL J · 2002 to 2025
$17.5M
TRANSFORMING GROWTH FACTORS IN COLONIC NEOPLASIAR01CA046413 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 1988 to 2016
$8.8M
Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
Roles for Lrig1 in Intestinal NeoplasiaR01CA151566 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2010 to 2016
$2.1M
CELL CYCLE, DEVELOPMENT, AND NEOPLASIAR01CA063677 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI DOVE, WILLIAM FRANKLIN · 1993 to 2012
$1.4M
Howard Hughes Medical InstituteNCI NIH HHS CA089713NCI NIH HHS P30 CA0142520NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA046413NCI NIH HHS R01 CA063677NCI NIH HHS R01 CA089713NCI NIH HHS R01 CA 151566NCI NIH HHS R01 CA151566NCI NIH HHS R01 CA 46413NCI NIH HHS T32 CA119925NIDDK NIH HHS P30 DK058404PHS HHS P50 95103
6 · The paper itself

Abstract

In October 2010, a pathology review of rodent models of intestinal neoplasia was held at The Jackson Laboratory. This review complemented 2 other concurrent events: a workshop on methods of modeling colon cancer in rodents and a conference on current issues in murine and human colon cancer. We summarize the results of the pathology review and the committee's recommendations for tumor nomenclature. A virtual high-resolution image slide box of these models has been developed. This report discusses significant recent developments in rodent modeling of intestinal neoplasia, including the role of stem cells in cancer and the creation of models of metastatic intestinal cancer.

Indexed as

Guidelines as TopicAnimalsBiopsy, NeedleColorectal NeoplasmsDisease Models, AnimalEducationHumansImmunohistochemistryIntestinal NeoplasmsMiceNeoplasm InvasivenessNeoplasm StagingResearch ReportRodentiaSampling StudiesSpecies Specificity

Identifiers

PMID23415801
PMCPMC3660997
OpenAlexW1965369905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.