ArticlePhysiology & behavior2013
Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians.
Article in Physiology & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Retention and Distribution of Dopamine-Dependent Reward Memory in Regenerating Planaria.Biomolecules · 2026Article
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- Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.International journal of molecular sciences · 2023Article
- Energy drink produces aversive effects in planarians.Physiology & behavior · 2022Article
- Nicotine-induced C-shape movements in planarians are reduced by antinociceptive drugs: Implications for pain in planarian paroxysm etiology?Brain research · 2022Article
- Kratom pharmacology: Clues from planarians exposed to mitragynine.Physiology & behavior · 2021Article
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- Predator odor produces anxiety-like behavioral phenotype in planarians that is counteracted by fluoxetine.Physiology & behavior · 2019Article
- Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians.Neuroscience · 2018Article
- Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian.Psychopharmacology · 2018Article
- Behavioral effects of Splenda, Equal and sucrose: Clues from planarians on sweeteners.Neuroscience letters · 2017Article
- Benzodiazepine inhibits anxiogenic-like response in cocaine or ethanol withdrawn planarians.Behavioural pharmacology · 2016Article
- Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates.Neuropharmacology · 2015Article
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- Ethanol and cocaine: environmental place conditioning, stereotypy, and synergism in planarians.Alcohol (Fayetteville, N.Y.) · 2014Article
- Levamisole and cocaine synergism: a prevalent adulterant enhances cocaine's action in vivo.Neuropharmacology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sucrose produces physical dependence and reinforcing effects in rats. We hypothesized that similar effects could be demonstrated in planarians, the earliest animal with a centralized nervous system. We used two assays, one that quantifies withdrawal responses during drug absence as a reduction in motility and another that quantifies reinforcing effects using a conditioned place preference (CPP) design. In withdrawal experiments, planarians exposed to sucrose (1%) for 60 min and then tested in water for 5 min displayed reduced motility compared to water controls. Acute or continuous sucrose (1%) exposure did not affect motility. CPP experiments used a biased design to capitalize upon planarians' natural preference for the dark (pretest, sucrose conditioning in the light, posttest). Planarians conditioned with sucrose (1%) displayed a greater preference shift than sucrose-naïve planarians. Glucose (0.1, 1%), but not the non-digestible disaccharide lactulose (0.1, 1%), also produced a greater preference shift than water-exposed planarians. Development of sucrose-induced CPP was inhibited when sucrose (1%) conditioning was conducted in combination with dopamine receptor antagonists SCH 23390 (1 μM) or sulpiride (1 μM). These results suggest that the rewarding and reinforcing effects of sugar are highly conserved across species and that planarians offer an invertebrate model to provide insight into the pharmacological effects of sucrose and related sweeteners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.