ReviewBiochimie2013
Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.
Review in Biochimie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Vitamin B12 supplementation for growth, development, and cognition in children.The Cochrane database of systematic reviews · 2026Pooled it
- Vitamin B12 supplementation during pregnancy for maternal and child health outcomes.The Cochrane database of systematic reviews · 2024Pooled it
- Neuroprotective crosstalk from vitamin B12 and sphingolipid signaling pathways in therapy for multiple sclerosis.International immunology · 2026Review
- The Role of Cobalt Ions in Angiogenesis-A Review.International journal of molecular sciences · 2025Review
- CD320 Receptor and Vitamin B12 as Potential Targets for Anti-Cancer Therapy.International journal of molecular sciences · 2025Review
- CD302 regulates the malignant phenotypes of lung adenocarcinoma as a tumor suppressor gene.Frontiers in oncology · 2025Article
- From Pancytopenia to Hyperleukocytosis, an Unexpected Presentation of Immune Reconstitution Inflammatory Syndrome in an Infant with Methylmalonic Acidemia.Children (Basel, Switzerland) · 2024Article
- Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.Annals of hematology · 2024Article
- Dysregulation of iron transport-related biomarkers in blood leukocytes is associated with poor prognosis of early trauma.Heliyon · 2024Article
- Nutrient intake and risk of multimorbidity: a prospective cohort study of 25,389 women.BMC public health · 2024Article
- Kinetics of Cellular Cobalamin Uptake and Conversion: Comparison of Aquo/Hydroxocobalamin to Cyanocobalamin.Nutrients · 2024Article
- Proteomic and transcriptomic analyses identify apo-transcobalamin-II as a biomarker of overall survival in osteosarcoma.Frontiers in oncology · 2024Article
- FTY720 requires vitamin BCell reports · 2023Article
- Vitamin B12 in Cats: Nutrition, Metabolism, and Disease.Animals : an open access journal from MDPI · 2023Review
- Cobalamin (Vitamin B12) in Anticancer Photodynamic Therapy with Zn(II) Phthalocyanines.International journal of molecular sciences · 2023Article
- Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans.Scientific reports · 2023Article
- Vitamin BMolecules (Basel, Switzerland) · 2022Review
- Engineering Light-Control in Biology.Frontiers in bioengineering and biotechnology · 2022Review
- Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People.Nutrients · 2021Review
- The avian retroviral receptor Tva mediates the uptake of transcobalamin bound vitamin B12 (cobalamin).Journal of virology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cellular uptake of cobalamin is facilitated by a receptor-mediated endocytosis process involving transcobalamin, a plasma protein that binds cobalamin and a cell surface receptor that specifically binds transcobalamin saturated with cobalamin. Intracellular Cbl concentration is maintained by modulating the expression of the receptor, which is cell cycle associated with highest expression in actively proliferating cells and an efflux system that shunts the excess cobalamin out of the cells for mobilization to other tissues where it is most needed. This review describes the process, proteins involved and genes encoding these proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.