Trial reportThe Journal of pediatrics2013
Oral sucrose for heel lance increases adenosine triphosphate use and oxidative stress in preterm neonates.
Trial report in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04560374 (The Effect of Using Crochet Octopus in Reducing The Pain Developed During The Process of Heel Lance İn Neonates), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Using Crochet Octopus in Reducing The Pain Developed During The Process of Heel Lance İn Neonates: A Randomized Controlled Study
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Sucrose or glucose compared to breast milk for pain control in preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Sucrose analgesia for heel-lance procedures in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Sucrose for analgesia in newborn infants undergoing painful procedures.The Cochrane database of systematic reviews · 2016Pooled it
- A pilot study on the biochemical effects of repeated administration of 24% oral sucrose vs. 30% oral dextrose on urinary markers of adenosine triphosphate degradation.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Sucrose and warmth for analgesia in healthy newborns: an RCT.Pediatrics · 2015Trial
- Trial
- Sweet relief or lasting impacts? Review of neonatal pain and sucrose in developing rodents.Pain reports · 2025Article
- Neonatal Sucrose and Internalizing Behaviors at 18 Months in Children Born Very Preterm.JAMA network open · 2025Article
- Energy Utilization in Premature Neonates Undergoing Screening for Retinopathy of Prematurity.Pediatric reports · 2025Article
- A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates.Paediatric & neonatal pain · 2024Article
- Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials.BMC pediatrics · 2024Article
- Assessment and Management of Pain in Preterm Infants: A Practice Update.Children (Basel, Switzerland) · 2022Review
- Effect of music (Brahms lullaby) and non-nutritive sucking on heel lance in preterm infants: A randomized controlled crossover trial.Paediatrics & child health · 2019Article
- A Review of Non-Pharmacological Treatments for Pain Management in Newborn Infants.Children (Basel, Switzerland) · 2018Review
- The Energy Costs of Prematurity and the Neonatal Intensive Care Unit (NICU) Experience.Antioxidants (Basel, Switzerland) · 2018Review
- Article
- Urinary Allantoin Is Elevated in Severe Intraventricular Hemorrhage in the Preterm Newborn.Translational stroke research · 2016Article
- Oral sucrose for heel lance enhances adenosine triphosphate use in preterm neonates with respiratory distress.SAGE open medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the effects of sucrose on pain and biochemical markers of adenosine triphosphate (ATP) degradation and oxidative stress in preterm neonates experiencing a clinically required heel lance. STUDY
designPreterm neonates that met study criteria (n = 131) were randomized into 3 groups: (1) control; (2) heel lance treated with placebo and non-nutritive sucking; and (3) heel lance treated with sucrose and non-nutritive sucking. Plasma markers of ATP degradation (hypoxanthine, xanthine, and uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured with the Premature Infant Pain Profile. Data were analyzed by the use of repeated-measures ANOVA and Spearman rho.
resultsWe found significant increases in plasma hypoxanthine and uric acid over time in neonates who received sucrose. We also found a significant negative correlation between pain scores and plasma allantoin concentration in a subgroup of neonates who received sucrose.
conclusionA single dose of oral sucrose, given before heel lance, significantly increased ATP use and oxidative stress in premature neonates. Because neonates are given multiple doses of sucrose per day, randomized trials are needed to examine the effects of repeated sucrose administration on ATP degradation, oxidative stress, and cell injury.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.