Evidence map›Paper›PMID 23415267›Full record

ReviewClinics in perinatology2013

Inflammatory signaling in necrotizing enterocolitis.

Isabelle G De Plaen

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis.Journal of visualized experiments : JoVE · 2022
    Article
  12. PeptideFrontiers in nutrition · 2022
    Article
  13. Article
  14. Review
  15. Necrotizing Enterocolitis: Overview on In Vitro Models.International journal of molecular sciences · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Isabelle G De PlaenDivision of Neonatology, Department of Pediatrics, Children's Hospital of Chicago Research Center, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Box 45, Chicago, IL 60611-2605, USA. isabelledp@northwestern.edu

Funding

Cell-specific role of NF-KB in necrotizing enterocolitisR01HD060876 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2010 to 2014
$1.5M
NICHD NIH HHS R01 HD060876
6 · The paper itself

Abstract

The pathogenesis of necrotizing enterocolitis (NEC) is complex and its speed of progression is variable. To gain understanding of the disease, researchers have examined tissues resected from patients with NEC; however, as these are obtained at late stages of the disease, they do not yield clues about the early pathogenic events leading to NEC. Therefore, animal models are used and have helped identify a role for several mediators of the inflammatory network in NEC. In this article, we discuss the evidence for the role of these inflammatory mediators and conclude with a current unifying hypothesis regarding NEC pathogenesis.

Indexed as

AnimalsDisease Models, AnimalEnterocolitis, NecrotizingHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInflammationInflammation MediatorsMiceRatsSignal TransductionInflammation Mediators

Identifiers

PMID23415267
PMCPMC3579498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.