Evidence map›Paper›PMID 23415156›Full record

ReviewTrends in endocrinology and metabolism: TEM2013

Role of ABC transporters in lipid transport and human disease.

Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter A Edwards

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 1 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 1 synthesis or guideline pooled it, 291 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. A Neutral Triple-Helix Pomegranate (Journal of agricultural and food chemistry · 2026
    Article
  9. Article
  10. Review
  11. Integrative transcriptomic and lipidomic analysis of the effects ofFrontiers in cellular and infection microbiology · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Lipid Dysregulation in Tangier Disease: A Case Series and Metabolic Characterization.The Journal of clinical endocrinology and metabolism · 2025
    Article
  18. Review
  19. Article
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Elizabeth J TarlingDepartment of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. etarling@mednet.ucla.edu
Thomas Q de Aguiar Vallim
Peter A Edwards
University of California, Los Angeles · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
NHLBI NIH HHS HL30568NHLBI NIH HHS P01 HL030568
6 · The paper itself

Abstract

Almost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids. Mutations in a substantial number of the 48 human ABC transporters have been linked to human disease. Indeed the finding that 12 diseases have been associated with abnormal lipid transport and/or homeostasis demonstrates the importance of this family of transporters in cell physiology. This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders.

Indexed as

HomeostasisLipid MetabolismModels, BiologicalAnimalsATP-Binding Cassette TransportersBiological TransportGenetic Diseases, InbornHumansLipid Metabolism DisordersMutationATP-Binding Cassette Transporters

Identifiers

PMID23415156
PMCPMC3659191
OpenAlexW2161926177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.