Evidence map›Paper›PMID 23415155›Full record

ArticleAdvances in applied microbiology2013

Mechanisms of immune evasion in leishmaniasis.

Gaurav Gupta, Steve Oghumu, Abhay R Satoskar

Open access · bronzeAbstract read
In one paragraph

Article in Advances in applied microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
78.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 251 citations in OpenAlex.

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  16. An inclusive assessment of apoptosis mechanisms inCurrent research in parasitology & vector-borne diseases · 2025
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gaurav GuptaDepartment of Pathology, The Ohio State University Medical Center, Columbus, OH, USA; These authors contributed equally to this work.
Steve Oghumu
Abhay R Satoskar
The Ohio State University · USThe Ohio State University Wexner Medical Center · US

Funding

Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
Development of novel therapeutics for a neglected tropical disease leishmaniasisRC4AI092624 · NIAID · OHIO STATE UNIVERSITY · PI KINGHORN, ALAN DOUGLAS, SATOSKAR, ABHAY R · 2010 to 2010
$2.6M
Discovery of novel antileishmanial molecules from the plant Pentalinon andreuxiiR56AI090803 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2010 to 2010
$804k
Isolation of novel antileishmanial molecules from Pentalinon andrieuxii rootR21AI076309 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2008 to 2009
$413k
Treatment of cutaneous leishmaniasis using Pentalinon andrieuxii root extractR21AT004160 · NCCIH · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2009 to 2010
$411k
Visualization of CXCR3 allelic usage in vivoR03AI090231 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2010 to 2011
$242k
Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapyR34AI100789 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2012 to 2012
$229k
Chemopreventition and treatment of non-melanoma skin cancer by targeting MIFR03CA164399 · NCI · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2012 to 2013
$153k
NCCIH NIH HHS R21 AT004160NCCIH NIH HHS R21AT004160NCI NIH HHS R03 CA164399NCI NIH HHS R03CA164399NIAID NIH HHS R03 AI090231NIAID NIH HHS R03AI090231NIAID NIH HHS R21 AI076309NIAID NIH HHS R34 AI100789NIAID NIH HHS R34AI100789NIAID NIH HHS R56 AI090803NIAID NIH HHS RC4 AI092624NIAID NIH HHS RC4AI092624NIDCR NIH HHS T32 DE014320NIDCR NIH HHS T32DE014320
6 · The paper itself

Abstract

Diseases caused by Leishmania present a worldwide problem, and current therapeutic approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells by evading or exploiting host immune mechanisms. A thorough understanding of these mechanisms could lead to better strategies for effective management of Leishmania infections. Current research has focused on parasite modification of host cell signaling pathways, entry into phagocytic cells, and modulation of cytokine and chemokine profiles that alter immune cell activation and trafficking to sites of infection. Immuno-therapeutic approaches that target these mechanisms of immune evasion by Leishmania offer promising areas for preclinical and clinical research.

Indexed as

Immune EvasionLeishmaniasisCytokinesHumansLeishmaniaSignal TransductionCytokines

Identifiers

PMID23415155
PMCPMC3697132
OpenAlexW1490606958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.