ArticleCell host & microbe2013
Xanthomonas type III effector XopD desumoylates tomato transcription factor SlERF4 to suppress ethylene responses and promote pathogen growth.
Article in Cell host & microbe, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Pooled it
- SUMOylation: an emerging field of protein modification in horticultural plants.Horticulture research · 2026Review
- SUMOylation in plants: A versatile post-translational mechanism responding to environmental stresses.Journal of integrative plant biology · 2026Review
- Reprogramming of bacterial virulence by lysine acetylation.Nature communications · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- The Candidate Effector Cgmas2 Orchestrates Biphasic Infection ofInternational journal of molecular sciences · 2026Article
- Woody Host-Specific Type III Effector HopBL2 Is Essential for Pseudomonas savastanoi Virulence and Associates With Plasmodesmata.Molecular plant pathology · 2025Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Decoding Plant-Pathogen Interactions: A Comprehensive Exploration of Effector-Plant Transcription Factor Dynamics.Molecular plant pathology · 2025Review
- Review
- Heat-induced SUMOylation differentially affects bacterial effectors in plant cells.The Plant cell · 2024Article
- Widespread Bradyrhizobium distribution of diverse Type III effectors that trigger legume nodulation in the absence of Nod factor.The ISME journal · 2023Article
- Nuclear effectors of plant pathogens: Distinct strategies to be one step ahead.Molecular plant pathology · 2023Review
- Effector-Dependent and -Independent Molecular Mechanisms of Soybean-Microbe Interaction.International journal of molecular sciences · 2022Review
- A Pan-Global Study of Bacterial Leaf Spot of Chilli Caused byPlants (Basel, Switzerland) · 2022Review
- MoIug4 is a novel secreted effector promoting rice blast by counteracting host OsAHL1-regulated ethylene gene transcription.The New phytologist · 2022Article
- A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component.The EMBO journal · 2022Article
- Article
- Plant susceptible responses: the underestimated side of plant-pathogen interactions.Biological reviews of the Cambridge Philosophical Society · 2022Review
- A bHLH transcription factor, SlbHLH96, promotes drought tolerance in tomato.Horticulture research · 2022Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
XopD, a type III secretion effector from Xanthomonas euvesicatoria (Xcv), the causal agent of bacterial spot of tomato, is required for pathogen growth and delay of host symptom development. XopD carries a C-terminal SUMO protease domain, a host range determining nonspecific DNA-binding domain and two EAR motifs typically found in repressors of stress-induced transcription. The precise target(s) and mechanism(s) of XopD are obscure. We report that XopD directly targets the tomato ethylene responsive transcription factor SlERF4 to suppress ethylene production, which is required for anti-Xcv immunity and symptom development. SlERF4 expression was required for Xcv ΔxopD-induced ethylene production and ethylene-stimulated immunity. XopD colocalized with SlERF4 in subnuclear foci and catalyzed SUMO1 hydrolysis from lysine 53 of SlERF4, causing SlERF4 destabilization. Mutation of lysine 53 prevented SlERF4 sumoylation, decreased SlERF4 levels, and reduced SlERF4 transcription. These data suggest that XopD desumoylates SlERF4 to repress ethylene-induced transcription required for anti-Xcv immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.