ArticleAlcohol (Fayetteville, N.Y.)2013
Selective breeding for ethanol-related traits alters circadian phenotype.
Article in Alcohol (Fayetteville, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Ovarian influence on circadian and infradian modulation of nicotine-seeking in female mice.Journal of neuroendocrinology · 2026Article
- Editorial: The role, and underlying neural mechanisms of, physical activity in treating substance and alcohol use disorders.Frontiers in integrative neuroscience · 2025Article
- Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice.Frontiers in behavioral neuroscience · 2023Article
- Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression.International journal of molecular sciences · 2022Article
- The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice.Alcohol (Fayetteville, N.Y.) · 2021Article
- Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice.Alcoholism, clinical and experimental research · 2021Article
- Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes.Brain sciences · 2020Article
- Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity.Physiology & behavior · 2016Article
- Mutations in the circadian gene period alter behavioral and biochemical responses to ethanol in Drosophila.Behavioural brain research · 2016Article
- Circadian clock genes: effects on dopamine, reward and addiction.Alcohol (Fayetteville, N.Y.) · 2015Review
- Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Circadian rhythms and addiction: mechanistic insights and future directions.Behavioral neuroscience · 2014Review
- Circadian abnormalities in a mouse model of high trait anxiety and depression.Annals of medicine · 2014Article
- High drinking in the dark mice: a genetic model of drinking to intoxication.Alcohol (Fayetteville, N.Y.) · 2014Review
- A model of alcohol drinking under an intermittent access schedule using group-housed mice.PloS one · 2014Article
- The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels.Behavioural brain research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies in mice and rats have shown that selective breeding for high and low ethanol preference results in divergence of circadian phenotype in the selected lines. These results indicate that some alleles influencing ethanol preference also contribute to circadian rhythm regulation. Selective breeding has also been used to produce lines of mice differing in a number of other ethanol-related traits, while studies of phenotypic and genetic correlation indicate that diverse ethanol-related traits are influenced by both shared and unshared genetics. In the present study, we examined several features of circadian activity rhythms in a mouse line selected for binge-like drinking and in mouse lines selected for high and low severity of ethanol withdrawal convulsions. Specifically, Experiment 1 compared High Drinking in the Dark (HDID-1) mice to their genetically heterogeneous progenitor line (HS/Npt), and Experiment 2 compared Withdrawal Seizure-Prone (WSP-2) and Withdrawal Seizure-Resistant (WSR-2) mice. Both line pairs displayed differences in their daily activity patterns under light-dark conditions. In addition, HDID-1 mice showed shorter free-running periods in constant light and less coherent activity rhythms across lighting conditions relative to HS/Npt controls, while WSP-2 mice showed longer free-running periods in constant darkness relative to WSR-2 mice. These results strengthen the evidence for genetic linkages between responsiveness to ethanol and circadian regulation, and extend this evidence to include ethanol-related phenotypes other than preference drinking. However, the present results also indicate that the nature of genetic correlations between and within phenotypic domains is highly complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.