Evidence map›Paper›PMID 23414678›Full record

ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2013

Magnetic resonance of calcified tissues.

Felix W Wehrli

Open access · greenAbstract readReview
In one paragraph

Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 80 citations in OpenAlex.

  1. A CombinedAnnals of biomedical engineering · 2026
    Article
  2. Fast 3D UTE in vivo TMagnetic resonance in medicine · 2026
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  8. Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Felix W WehrliLaboratory for Structural NMR Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, USA. wehrli@mail.med.upenn.edu
University of Pennsylvania · US

Funding

Bone Water &Mineralization: Nuclear Magnetic ResonanceR01AR050068 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2003 to 2022
$4.9M
NIAMS NIH HHS R01 AR050068
6 · The paper itself

Abstract

MRI of the human body is largely made possible by the favorable relaxation properties of protons of water and triacyl glycerides prevalent in soft tissues. Hard tissues--key among them bone--are generally less amenable to measurement with in vivo MR imaging techniques, not so much as a result of the lower proton density but rather due to the extremely short life-times of the proton signal in water bound to solid-like entities, typically collagen, or being trapped in micro-pores. Either mechanism can enhance T2 relaxation by up to three orders of magnitude relative to their soft-tissue counterparts. Detection of these protons requires solid-state techniques that have emerged in recent years and that promise to add a new dimension to the study of hard tissues. Alternative approaches to probe calcified tissues exploit their characteristic magnetic properties. Bone, teeth and extra-osseous calcium-containing biomaterials are unique in that they are more diamagnetic than all other tissues and thus yield information indirectly by virtue of the induced magnetic fields present in their vicinity. Progress has also been made in methods allowing very high-resolution structural imaging of trabecular and cortical bone relying on detection of the surrounding soft-tissues. This brief review, much of it drawn from work conducted in the author's laboratory, seeks to highlight opportunities with focus on early-stage developments for image-based assessment of structure, function, physiology and mechanics of calcified tissues in humans via liquid and solid-state approaches, including proton, deuteron and phosphorus NMR and MRI.

Indexed as

Absorptiometry, PhotonAlgorithmsAnimalsBody WaterBone and BonesBone DensityBone MarrowCalcification, PhysiologicCollagenDiffusion Magnetic Resonance ImagingElectromagnetic FieldsFourier AnalysisHumansMagnetic Resonance ImagingCollagen

Identifiers

PMID23414678
PMCPMC4746726
OpenAlexW1977430638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.