ArticleBMC medical ethics2013
Effect of child health status on parents' allowing children to participate in pediatric research.
Article in BMC medical ethics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Motivations of children and their parents to participate in drug research: a systematic review.European journal of pediatrics · 2016Pooled it
- Stakeholder views and attitudes towards prenatal and postnatal transplantation of fetal mesenchymal stem cells to treat Osteogenesis Imperfecta.European journal of human genetics : EJHG · 2019Trial
- Investigating the Experiences of Childhood Cancer Patients and Parents Participating in Optional Nontherapeutic Clinical Research Studies in the UK.Pediatric blood & cancer · 2016Trial
- Determinants of Infant Participation and Non-Participation in Primary Prevention Trials.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2026Article
- Mitigating the impact of study-start delays in clinical trials for rare disorders: insights and lessons from a PKAN trial.Orphanet journal of rare diseases · 2025Article
- From opt-out to opt-in consent for secondary use of medical data and residual biomaterial: An evaluation using the RE-AIM framework.PloS one · 2024Article
- Parents' views of psychological research with children: Barriers, benefits, personality, and psychopathology.PloS one · 2023Article
- Reasons for participation in a child development study: Are cases with developmental diagnoses different from controls?Paediatric and perinatal epidemiology · 2022Article
- Maternal Perceptions of Safeguards for Research Involving Children.Journal of child and family studies · 2022Article
- Monitoring the recovery time of children after tonsillectomy using commercial activity trackers.European journal of pediatrics · 2021Observational
- Burden or Opportunity? Parent Experiences When Approached for Research in a Pediatric Intensive Care Unit.Ethics & human research · 2019Article
- Article
- Ethical considerations of researchers conducting pediatric clinical drug trials: a qualitative survey in two Belgian university children's hospitals.European journal of pediatrics · 2018Article
- Barriers and facilitators to clinical trial participation among parents of children with pediatric neuromuscular disorders.Clinical trials (London, England) · 2018Article
- Article
- Factors Affecting Recruitment of Participants for Studies of Diabetes Technology in Newly Diagnosed Youth with Type 1 Diabetes: A Qualitative Focus Group Study with Parents and Children.Diabetes technology & therapeutics · 2016Article
- "Watching time tick by…": Decision making for Duchenne muscular dystrophy trials.Contemporary clinical trials · 2016Article
- Quality of life in parents of preterm infants in a randomized nutritional intervention trial.Food & nutrition research · 2016Article
- Are Parents of Preschool Children Inclined to Give Consent for Participation in Nutritional Clinical Trials?PloS one · 2016Article
- Why do children decide not to participate in clinical research: a quantitative and qualitative study.Pediatric research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify motivational factors linked to child health status that affected the likelihood of parents' allowing their child to participate in pediatric research.
methodsParents were invited to return their completed questionnaires anonymously to assess motivational factors and factors that might improve participation in pediatric research.
resultsOf 573 eligible parents, 261 returned the completed questionnaires. Of these, 126 were parents of healthy children (group 1), whereas 135 were parents of sick children who were divided into two groups according to the severity of their pathology, i.e., 99 ambulatory children (group 2) and 36 nonambulatory children (group 3). The main factor motivating participation in a pediatric clinical research study was "direct benefits for their child" (87.7%, 100%, and 100% for groups 1, 2, and 3, respectively). The other factors differed significantly between the three groups, depending on the child's health status (all p < 0.05). Factors that might have a positive impact on parental consent to the participation of their child in a pediatric clinical research study differed significantly (χ2 test, all p ≤ 0.04), depending on the child's health status. The main factor was "a better understanding of the study and its regulation" for the healthy children and ambulatory sick children groups (31.2% and 82.1%, respectively), whereas this was the third factor for the nonambulatory sick children group (50%).
conclusionsInnovative strategies should be developed based on a child's health status to improve information provision when seeking a child's participation in pediatric research. Parents would like to spend more time in discussions with investigators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.