Evidence map›Paper›PMID 23414360›Full record

ReviewExpert review of proteomics2013

Emerging protein array technologies for proteomics.

Jung-Rok Lee, Dewey Mitchell Magee, Richard Samuel Gaster, Joshua LaBaer, Shan X Wang

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of proteomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multiphoton-Polymerized 3D Protein Assay.ACS applied materials & interfaces · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Proteomic Monitoring of B Cell Immunity.Methods in molecular biology (Clifton, N.J.) · 2016
    Article
  11. Review
  12. Integrated Microfluidics for Protein Modification Discovery.Molecular & cellular proteomics : MCP · 2015
    Article
  13. Review
  14. Carbon Substrates: A Stable Foundation for Biomolecular Arrays.Annual review of analytical chemistry (Palo Alto, Calif.) · 2015
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jung-Rok LeeDepartment of Mechanical Engineering, Stanford University, 476 Lomita Mall, Room 208, Stanford, CA 94305, USA.
Dewey Mitchell Magee
Richard Samuel Gaster
Joshua LaBaer
Shan X Wang
Arizona State University · USStanford University · US

Funding

TRANS-NETWORK PROJECTSU54CA143907 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HILLIS, WILLIAM DANIEL · 2009 to 2013
$15.2M
Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
Cancer Sample Preparation with Micromachined Magnetic Sifter and NanoparticlesR33CA138330 · NCI · STANFORD UNIVERSITY · PI WAKELEE, HEATHER ANN, WANG, SHAN X. · 2010 to 2012
$738k
NCI NIH HHS R33 CA138330NCI NIH HHS R33CA138330NCI NIH HHS U54 CA143907NCI NIH HHS U54CA143907NCI NIH HHS U54 CA151459NCI NIH HHS U54CA151459
6 · The paper itself

Abstract

Numerous efforts have been made to understand fundamental biology of diseases based on gene expression. However, the relationship between gene expression and onset of disease often remains obscure. The great advances in protein microarrays allow us to investigate this unclear question through protein profiles, which are regarded as more reliable than gene expressions to serve as the harbinger of disease onset or as the biomarker of disease treatment monitoring. The authors review two relatively new platforms of protein arrays, along with an introduction to the common basis of protein array technologies. Immobilization of proteins on the surface of arrays and neutralizing reactive areas after the immobilization are key practical issues in the field of protein array. One of the emerging protein array technologies is the magneto-nanosensor array, where giant magnetoresistive sensors are used to quantitatively measure the analytes of interest, which are labeled with magnetic nanoparticles. Similar to giant magnetoresistive sensors, several different ways of utilizing magnetic properties for biomolecular detection have been developed and are reviewed here. Another emerging protein array technology is nucleic acid programmable protein arrays, which have thousands of protein features directly expressed by nucleic acids on the array surface. The authors anticipate that these two emerging protein array platforms can be combined to produce synergistic benefits and open new applications in proteomics and clinical diagnostics.

Indexed as

AnimalsHumansMagnetsNanotechnologyOligonucleotide Array Sequence AnalysisProtein Array AnalysisProteomics

Identifiers

PMID23414360
PMCPMC4143142
OpenAlexW2011045305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.