Evidence map›Paper›PMID 23414324›Full record

ArticleEpigenomics2013

The regulation of mammalian mRNA transcription by lncRNAs: recent discoveries and current concepts.

Jennifer F Kugel, James A Goodrich

Abstract read
In one paragraph

Article in Epigenomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. LncRNAs in vascular biology and disease.Vascular pharmacology · 2019
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Long noncoding RNAs and tumorigenesis: genetic associations, molecular mechanisms, and therapeutic strategies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer F KugelDepartment of Chemistry & Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA.
James A Goodrich

Funding

Regulation of RNA polymerase ll by small RNAsR01GM068414 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI GOODRICH, JAMES · 2003 to 2018
$5.1M
NIGMS NIH HHS R01 GM068414
6 · The paper itself

Abstract

Transcription by RNA Pol II is a tightly controlled process that is critical to normal cellular metabolism. Understanding how transcriptional regulation is orchestrated has mainly involved identifying and characterizing proteins that function as transcription factors. During the past decade, however, an increasing number of lncRNAs have been identified as transcriptional regulators. This revelation has spurred new discoveries, novel techniques and paradigm shifts, which together are redefining our understanding of transcriptional control and broadening our view of RNA function. Here, we summarize recent discoveries concerning the role of lncRNAs as regulators of mammalian mRNA transcription, with a focus on key concepts that are guiding current research in the field.

Indexed as

Transcription, GeneticAnimalsChromatinChromatin Assembly and DisassemblyGene Expression RegulationHumansRNA, Long NoncodingRNA, MessengerRNA Polymerase IIChromatinRNA, Long NoncodingRNA, MessengerRNA Polymerase II

Identifiers

PMID23414324
PMCPMC3702037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.