ArticleLipids in health and disease2013
Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in adolescents: the healthy young cross-sectional study.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 40 citations in OpenAlex.
- Fatty Acids in Childhood Obesity: A Link Between Nutrition, Metabolic Alterations and Cardiovascular Risk.Journal of lipid and atherosclerosis · 2025Article
- Age- and Sex-Specific Association between Lipoprotein-Related Phospholipase A2 and Cardiometabolic Risk Factors.International journal of molecular sciences · 2023Article
- Lipid Biomarkers and Atherosclerosis-Old and New in Cardiovascular Risk in Childhood.International journal of molecular sciences · 2023Review
- Correlation Between Lipoprotein-Related Phospholipase A2 and Metabolic Syndrome.International journal of general medicine · 2023Article
- Effect of Roux-en-Y Gastric Bypass on Lipoprotein Metabolism and Markers of HDL Functionality in Morbid Obese Patients.Obesity surgery · 2021Article
- Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV.AIDS (London, England) · 2019Article
- Lipoprotein-associated phospholipase A2 activity in obese adolescents with and without type 2 diabetes.Journal of inherited metabolic disease · 2018Article
- Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics.Medical sciences (Basel, Switzerland) · 2017Article
- Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress.Scientific reports · 2017Article
- Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure.PloS one · 2017Article
- Evaluation of lipoprotein-associated phospholipase A2 in healthy Chinese Han adult serum.Lipids in health and disease · 2014Article
- The correlation between lipoprotein associated phospholipase AInternational journal of immunopathology and pharmacologyArticle
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3 authors at 1 institution in 1 country.
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Abstract
backgroundLipoprotein-associated phospholipase A2 activity (Lp-PLA2) is a good marker of cardiovascular risk in adults. It is strongly associated with stroke and many others cardiovascular events. Despite this, the impact of obesity on this enzyme activity and its relation to biomarkers of cardiovascular disease in adolescents is not very well investigated. The purpose of this article is to evaluate the influence of obesity and cardiometabolic markers on Lp-PLA2 activity in adolescents.
resultsThis cross-sectional study included 242 adolescents (10-19 years) of both gender. These subjects were classified in Healthy Weight (n = 77), Overweight (n = 82) and Obese (n = 83) groups. Lipid profile, glucose, insulin, HDL size, LDL(-) and anti-LDL(-) antibodies were analyzed. The Lp-PLA2 activity was determined by a colorimetric commercial kit. Body mass index (BMI), waist circumference and body composition were monitored. Food intake was evaluated using three 24-hour diet recalls. The Lp-PLA2 activity changed in function to high BMI, waist circumference and fat mass percentage. It was also positively associated with HOMA-IR, glucose, insulin and almost all variables of lipid profile. Furthermore, it was negatively related to Apo AI (β = -0.137; P = 0.038) and strongly positively associated with Apo B (β = 0.293; P < 0.001) and with Apo B/Apo AI ratio (β = 0.343; P < 0.001). The better predictor model for enzyme activity, on multivariate analysis, included Apo B/Apo AI (β = 0.327; P < 0.001), HDL size (β = -0.326; P < 0.001), WC (β = 0.171; P = 0.006) and glucose (β = 0.119; P = 0.038). Logistic regression analysis demonstrated that changes in Apo B/Apo AI ratio were associated with a 73.5 times higher risk to elevated Lp-PLA2 activity.
conclusionsLp-PLA2 changes in function of obesity, and that it shows important associations with markers of cardiovascular risk, in particular with waist circumference, glucose, HDL size and Apo B/Apo AI ratio. These results suggest that Lp-PLA2 activity can be a cardiovascular biomarker in adolescence.
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