Trial reportCOPD2013
Racial differences in CT phenotypes in COPD.
Trial report in COPD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Bronchial wall parameters on CT in healthy never-smoking, smoking, COPD, and asthma populations: a systematic review and meta-analysis.European radiology · 2022Pooled it
- Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States.Annals of the American Thoracic Society · 2024Article
- The association of chest computed tomography-defined visual emphysema and prognosis in patients with nonsmall cell lung cancer.ERJ open research · 2023Article
- The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2023Review
- Serum YKL-40 Levels, Leukocyte Profiles, and Acute Exacerbations of Advanced COPD.Journal of clinical medicine · 2023Article
- Lung Imaging in COPD Part 2: Emerging Concepts.Chest · 2023Review
- Contribution of adaptive immunity to human COPD and experimental models of emphysema.Physiological reviews · 2023Review
- Article
- Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2021Article
- Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors.BMC pulmonary medicine · 2021Observational
- Progression of Emphysema and Small Airways Disease in Cigarette Smokers.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes.American journal of respiratory and critical care medicine · 2021Article
- A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk.Frontiers in genetics · 2020Article
- Review
- Imaging Advances in Chronic Obstructive Pulmonary Disease. Insights from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) Study.American journal of respiratory and critical care medicine · 2019Review
- Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease.ERJ open research · 2018Article
- Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort.BMC pulmonary medicine · 2018Article
- Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2017Article
- Identifying Patients With COPD at High Risk of Readmission.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016Article
- Sex-specific features of emphysema among current and former smokers with COPD.The European respiratory journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundWhether African Americans (AA) are more susceptible to COPD than non-Hispanic Whites (NHW) and whether racial differences in disease phenotype exist is controversial. The objective is to determine racial differences in the extent of emphysema and airway remodeling in COPD.
methodsFirst, 2,500 subjects enrolled in the COPDGene study were used to evaluate racial differences in quantitative CT (QCT) parameters of% emphysema, air trapping and airway wall thickness. Independent variables studied included race, age, gender, education, BMI, pack-years, smoking status, age at smoking initiation, asthma, previous work in dusty job, CT scanner and center of recruitment.
resultsOf the 1,063 subjects with GOLD Stage II-IV COPD, 200 self-reported as AA. AAs had a lower mean% emphysema (13.1% vs. 16.1%, p = 0.005) than NHW and proportionately less emphysema in the lower lung zones. After adjustment for covariates, there was no statistical difference by race in air trapping or airway wall thickness. Measured QCT parameters were more predictive of poor functional status in NHWs compared to AAs.
conclusionsAAs have less emphysema than NHWs but the same degree of airway disease. Additional factors not easily assessed by current QCT techniques may account for the poor functional status in AAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.