Evidence map›Paper›PMID 23413779›Full record

ArticleNutrition journal2013

Green tea intake is associated with urinary estrogen profiles in Japanese-American women.

Barbara J Fuhrman, Ruth M Pfeiffer, Anna H Wu, Xia Xu, Larry K Keefer, Timothy D Veenstra, Regina G Ziegler

Open access · goldAbstract read
In one paragraph

Article in Nutrition journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Herbal Treatments for Obesity: A Review.Current medicinal chemistry · 2025
    Review
  4. Article
  5. Markers of Local and Systemic Estrogen Metabolism in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Barbara J FuhrmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. bjfuhrman@uams.edu
Ruth M Pfeiffer
Anna H Wu
Xia Xu
Larry K Keefer
Timothy D Veenstra
Regina G Ziegler
National Institutes of Health · USUniversity of Arkansas for Medical Sciences · USDepartment of Health and Human Services · USFrederick National Laboratory for Cancer Research · USScience Applications International Corporation (United States) · US

Funding

Nutrition, Metabolism, and CancerZIACP010169 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$9.2M
Intramural NIH HHSPHS HHS HHSN261200800001E
6 · The paper itself

Abstract

scopeIntake of green tea may reduce the risk of breast cancer; polyphenols in this drink can influence enzymes that metabolize estrogens, known causal factors in breast cancer etiology. METHODS AND

resultsWe examined the associations of green tea intake (<1 time/week, 1-6 times weekly, or 7+ times weekly) with urinary estrogens and estrogen metabolites (jointly EM) in a cross-sectional sample of healthy Japanese American women, including 119 premenopausal women in luteal phase and 72 postmenopausal women. We fit robust regression models to each log-transformed EM concentration (picomoles per mg creatinine), adjusting for age and study center. In premenopausal women, intake of green tea was associated with lower luteal total EM (P trend=0.01) and lower urinary 16-pathway EM (P trend=0.01). In postmenopausal women, urinary estrone and estradiol were approximately 20% and 40% lower (P trend=0.01 and 0.05, respectively) in women drinking green tea daily compared to those drinking<1 time/week. Adjustment for potential confounders (age at menarche, parity/age at first birth, body mass index, Asian birthplace, soy) did not change these associations.

conclusionsFindings suggest that intake of green tea may modify estrogen metabolism or conjugation and in this way may influence breast cancer risk.

Indexed as

AsianFeeding BehaviorTeaAdultBody Mass IndexBreast NeoplasmsCross-Sectional StudiesEstrogensFemaleHumansLinear ModelsMiddle AgedMultivariate AnalysisPolyphenolsPostmenopausePremenopauseEstrogensPolyphenolsTea

Identifiers

PMID23413779
PMCPMC3584908
OpenAlexW2006440634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.