ArticleDeutsches Arzteblatt international2013
Increase in opiate prescription in Germany between 2000 and 2010: a study based on insurance data.
Article in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence.PloS one · 2019Pooled it
- Supervised dosing with a long-acting opioid medication in the management of opioid dependence.The Cochrane database of systematic reviews · 2017Pooled it
- [Opioids in chronic noncancer pain-are opioids superior to nonopioid analgesics? A systematic review and meta-analysis of efficacy, tolerability and safety in randomized head-to-head comparisons of opioids versus nonopioid analgesics of at least four week's duration].Schmerz (Berlin, Germany) · 2015Pooled it
- [Opioids in chronic noncancer pain-are opioids different? A systematic review and meta-analysis of efficacy, tolerability and safety in randomized head-to-head comparisons of opioids of at least four week's duration].Schmerz (Berlin, Germany) · 2015Pooled it
- [Long-term opioid therapy in chronic noncancer pain. A systematic review and meta-analysis of efficacy, tolerability and safety in open-label extension trials with study duration of at least 26 weeks].Schmerz (Berlin, Germany) · 2015Pooled it
- Educating physicians on strong opioids by descriptive versus simulated-experience formats: a randomized controlled trial.BMC medical education · 2022Trial
- [Opioid prescriptions for insured individuals without cancer in Germany: data from the BARMER].Schmerz (Berlin, Germany) · 2025Article
- Exceeding the guideline-recommended maximum daily dose of opioids for long-term treatment of non-cancer pain in Germany - a large retrospective observational study.BMC public health · 2024Observational
- Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors.Journal of medicinal chemistry · 2024Article
- Opioid exit plans for tapering postoperative pain control in noncancer patients: a systematic review.Patient safety in surgery · 2024Review
- Does opioid therapy enhance quality of life in patients suffering from chronic non-malignant pain? A systematic review and meta-analysis.British journal of pain · 2024Article
- [Dealing with "complex" pain patients in eye surgery : Perioperative management of patients with pre-existing chronic pain, opioid consumption and opioid use disorder].Die Ophthalmologie · 2023Review
- [Support of opioid rotation using online apps : Evaluation of applicability and comparison to the LONTS guidelines].Schmerz (Berlin, Germany) · 2023Article
- Republication of "How Will the Foot and Ankle Orthopedic Community Respond to the Growing Opioid Epidemic?"Foot & ankle orthopaedics · 2023Review
- Trends in opioid utilization in Hungary, 2006-2020: A nationwide retrospective study with multiple metrics.European journal of pain (London, England) · 2022Article
- [Critical discussion of new data regarding prevalence of opioid use disorder in patients with chronic pain in Germany].Schmerz (Berlin, Germany) · 2022Review
- Subtypes in Patients Taking Prescribed Opioid Analgesics and Their Characteristics: A Latent Class Analysis.Frontiers in psychiatry · 2022Article
- In-hospital postoperative opioid use and its trends in neurosurgery between 2007 and 2018.Acta neurochirurgica · 2022Article
- Evidence for the Effectiveness and Acceptability of e-SBI or e-SBIRT in the Management of Alcohol and Illicit Substance Use in Pregnant and Post-partum Women.Frontiers in psychiatry · 2021Review
- Trends in risky prescriptions of opioid analgesics from 2011 to 2015 in Northern Germany.Journal of psychopharmacology (Oxford, England) · 2020Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsufficient data have been available to date on the prevalence of opioid treatment in Germany, physicians' prescribing habits, and the percentages of cancer patients and non-cancer patients among those receiving opioids for an evaluation of the quality of care and an assessment of possible underuse or misuse.
methodsThe data analyzed in this study were derived from the statutory health insurance sample of the AOK health insurance company in the German state of Hesse / ASHIP Hesse for the years 2000-2010. For the purpose of this study, prevalence was defined as the percentage of insurees who received at least one outpatient prescription of an opioid (ATC N02A, excluding codeine, levomethadone and methadone). In order to control for population aging, the prevalence was standardized to the German population on December 31(st) of the preceding year and to the age-structure of the population as it was in 1999. Opioid prescribing for cancer was assumed when a cancer diagnosis was documented in the same year in which the opioid prescription was issued.
resultsThe percentage of insurees receiving at least one opioid prescription rose over the period of the study from 3.31% in 2000 to 4.53% in 2010, a relative gain of 37%. Opioids were mostly prescribed to patients with non-cancer pain (2010: about 77% of opioid recipients). The percentage of non-cancer patients receiving long-term opioid treatment has also increased over the period of the study.
conclusionAs opioids are frequently prescribed for non-cancer pain, it cannot be inferred from the observed increase in opioid prescribing that cancer patients are now receiving better opioid treatment than they were before. Further issues of concern are the observed increases in the prescribing of potent immediate release opioids and in the long-term opioid treatment for non-cancer patients, the benefit of which is currently debated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.