ArticleF1000 biology reports2013
PKM and the maintenance of memory.
Article in F1000 biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Revisiting the calpain hypothesis of learning and memory 40 years later.Frontiers in molecular neuroscience · 2024Review
- DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?Neural regeneration research · 2020Article
- Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
- PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Molecular Mechanisms of the Memory Trace.Trends in neurosciences · 2019Review
- Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats.Scientific reports · 2018Article
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- Long-term Potentiation Decay and Poor Long-lasting Memory Process in the Wild RodentsFrontiers in behavioral neuroscience · 2018Article
- Long-term habituation of the C-start escape response in zebrafish larvae.Neurobiology of learning and memory · 2016Article
- Atypical PKCs in memory maintenance: the roles of feedback and redundancy.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.Frontiers in cellular neuroscience · 2015Article
- Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia.eLife · 2014Article
- pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning.Nature communications · 2014Article
- KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ.Journal of neurochemistry · 2014Article
- Dynamic learning and memory, synaptic plasticity and neurogenesis: an update.Frontiers in behavioral neuroscience · 2014Review
- A biological perspective on memory.Current biology : CB · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging. A novel kinase, an isoform of protein kinase C (PKC), PKMzeta, has been shown to be critical to the maintenance of some types of memory. Inhibiting the catalytic properties of this kinase can erase well-established memories without altering the ability of the erased synapse to be retrained. This article provides an overview of the literature linking PKMzeta to memory maintenance and identifies some of the controversial issues that surround the bold implications of the existing data. It concludes with a discussion of the future directions of this domain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.