ArticleJournal of feline medicine and surgery2013
Prospective evaluation of healthy Ragdoll cats for chronic kidney disease by routine laboratory parameters and ultrasonography.
Article in Journal of feline medicine and surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Safety of Intraperitoneal Injection of Adipose Tissue-Derived Autologous Mesenchymal Stem Cells in Cats.Journal of veterinary internal medicineTrial
- Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease.Frontiers in veterinary science · 2025Article
- Urinary liver-type fatty acid-binding protein in clinically healthy elderly cats: Evaluation of its potential to detect IRIS stage 1 chronic kidney disease and borderline proteinuria.Veterinary medicine and science · 2023Article
- Haematological and biochemical reference intervals in healthy Ragdoll cats.Journal of feline medicine and surgery · 2022Article
- Machine-learning algorithm as a prognostic tool in non-obstructive acute-on-chronic kidney disease in the cat.Journal of feline medicine and surgery · 2021Article
- The ultrasonographic medullary "rim sign" versus medullary "band sign" in cats and their association with renal disease.Journal of veterinary internal medicine · 2020Article
- Feline abdominal ultrasonography: what's normal? what's abnormal? The kidneys and perinephric space.Journal of feline medicine and surgery · 2020Article
- Renal shear wave elastography and urinary procollagen type III amino-terminal propeptide (uPIIINP) in feline chronic kidney disease.BMC veterinary research · 2019Article
- Comparison of ultrasonographic findings in cats with and without azotaemia.Journal of feline medicine and surgery · 2018Article
- Systolic blood pressure, routine kidney variables and renal ultrasonographic findings in cats naturally infected with feline immunodeficiency virus.Journal of feline medicine and surgery · 2017Article
- Simplified methods for estimating glomerular filtration rate in cats and for detection of cats with low or borderline glomerular filtration rate.Journal of feline medicine and surgery · 2015Article
- Routine kidney variables, glomerular filtration rate and urinary cystatin C in cats with diabetes mellitus, cats with chronic kidney disease and healthy cats.Journal of feline medicine and surgery · 2015Article
- Factors affecting urine specific gravity in apparently healthy cats presenting to first opinion practice for routine evaluation.Journal of feline medicine and surgery · 2015Article
- Renal dimensions at ultrasonography in healthy Ragdoll cats with normal kidney morphology: correlation with age, gender and bodyweight.Journal of feline medicine and surgery · 2013Article
- Feline CKD: Diagnosis, staging and screening - what is recommended?Journal of feline medicine and surgery · 2013Review
- Biological variation of urinary protein: Creatinine ratio and urine specific gravity in cats.Journal of veterinary internal medicineArticle
- Diagnostic Value of Echocardiography in Cats With and Without Ultrasonographic Evidence of Renal Infarction.Journal of veterinary internal medicineArticle
- Effect of laboratory and sample storage factors on urinary protein:creatinine ratios and clinical decision making in cats.Journal of veterinary internal medicineArticle
- Concurrent diseases and conditions in cats with renal infarcts.Journal of veterinary internal medicineArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ragdoll breeder organisations often forewarn Ragdoll cat owners that renal problems may develop as a result of polycystic kidney disease (PKD), chronic interstitial nephritis, familial renal dysplasia or nephrocalcinosis. Healthy Ragdoll and non-Ragdoll cats were prospectively evaluated by measuring serum creatinine and urea concentrations, routine urinalysis and abdominal ultrasonography. All Ragdoll cats also underwent genetic PKD testing. One hundred and thirty-three Ragdoll and 62 control cats were included. Ragdoll cats had significantly lower serum urea concentrations and higher urinary specific gravity. However, median creatinine concentration, median urinary protein-to-creatinine ratio, and the proportion of cats with serum creatinine or urea concentration exceeding the reference interval did not differ. One or more renal ultrasonographical changes were detected in 66/133 (49.6%) Ragdoll and in 25/62 (40%) control cats. Ragdoll cats showed significantly more frequent segmental cortical lesions (7.5% versus 0%), abnormal renal capsule (19.5% versus 8%) and echogenic urine (51.9% versus 25.8%). Chronic kidney disease (CKD) was ultrasonographically suspected in 7/133 (5.3%) Ragdoll and in none of the control cats, which approached significance. Laboratory parameters confirmed kidney dysfunction only in 1/7 of these Ragdoll cats. All Ragdoll cats were PKD negative. In conclusion, first, breed-specific serum creatinine reference intervals are not likely required for Ragdoll cats. Second, renal ultrasonographical abnormalities are common, both in Ragdoll and non-Ragdoll cats. Third, healthy young Ragdoll cats are uncommonly affected by PKD and CKD, but an increased susceptibility of Ragdoll cats to develop CKD cannot be excluded. Finally, Ragdoll cats are predisposed to segmental cortical lesions, which may indicate renal infarction or cortical scarring.
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