ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Immunohistochemical Study of Diamine Oxidase at the Upper Gastrointestinal Tract in Patients With Gastrointestinal-Mediated Food Allergy.Allergy, asthma & immunology research · 2026Article
- Evidence for Dietary Management of Histamine Intolerance.International journal of molecular sciences · 2025Review
- [Functional study of amine oxidase copper-containing 1 (AOC1) in lipid metabolism].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Effect of L-Glutamine on Chylomicron Formation and Fat-Induced Activation of Intestinal Mucosal Mast Cells in Sprague-Dawley Rats.Nutrients · 2022Article
- Effect of a high-fat diet and chromium on hormones level and Cr retention in rats.Journal of endocrinological investigation · 2022Article
- Review
- The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut.International journal of molecular sciences · 2021Review
- Histamine Intolerance Originates in the Gut.Nutrients · 2021Review
- Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients.Postepy dermatologii i alergologii · 2019Article
- Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Toxicological safety evaluation of freeze-driedToxicology reports · 2018Article
- Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.Gastroenterology · 2016Article
- Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.Canadian journal of gastroenterology & hepatology · 2016Article
- Subchronic Oral Dose Toxicity of Freeze-dried Powder of Allomyrina dichotoma Larvae.Toxicological research · 2015Article
- Identification of genomic regions associated with feed efficiency in Nelore cattle.BMC genetics · 2014Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Diamine oxidase (DAO) is abundantly expressed in mammalian small intestine catalyzing the oxidative breakdown of polyamines and histamine. The aim of this study was to determine the relationship between stimulation of intestinal diamine oxidase secretion with intestinal fat absorption and histamine release. Conscious intestinal lymph fistula rats were used. The mesenteric lymph ducts were cannulated and intraduodenal tubes were installed for the infusion of Liposyn II 20% (an intralipid emulsion). Lymphatic DAO activity and protein secretion were analyzed by radiometric assay and Western blot, respectively. Lymphatic histamine concentration was measured by ELISA. Infusion of Liposyn II (4.43 kcal/3 ml) resulted in a ~3.5-fold increase in lymphatic DAO protein secretion and DAO activity, peaking at 1 h and lasting for 3 h. Liposyn II infusion also increased the lymphatic histamine release, a substrate for DAO. To determine the relationship of DAO release with histamine release, histamine was administered intraperitoneally (10 mg/kg) in fasting rats and resulted in a significant doubling in lymphatic DAO activity, supporting a link between histamine and DAO. In addition, ip administration of the histamine H4 receptor antagonist JNJ7777120 significantly reduced the Liposyn II-induced DAO output by 65.9%, whereas H(1) (pyrilamine maleate), H(2) (ranitidine), and H(3) (thioperamide maleate) receptor antagonists had little effect. We conclude that DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H(4) receptor.
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