ArticleAJNR. American journal of neuroradiology2013
Development of the fetal cerebral cortex in the second trimester: assessment with 7T postmortem MR imaging.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 52 citations in OpenAlex.
- Spatial transcriptomics reveal developmental dynamics of the human cerebral cortex and striatum.Science China. Life sciences · 2026Article
- Mapping Fetal Brain Development of 10 Weeks' Gestational Age with 9.4T Postmortem MRI and Histologic Sections.AJNR. American journal of neuroradiology · 2025Article
- DHARANI: A 3D Developing Human-Brain Atlas Resource to Advance Neuroscience Internationally Integrated Multimodal Imaging and High-Resolution Histology of the Second Trimester.The Journal of comparative neurology · 2025Article
- Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain.Developmental neuroscience · 2025Review
- Heterogeneity in the formation of primary and secondary visual fields during human prenatal development.Biological research · 2024Article
- A postmortem high-resolution MRI study of the development of cochlear nerve-related structures in the second and third trimesters of pregnancy.Quantitative imaging in medicine and surgery · 2024Article
- The superior frontal sulcus in the human brain: Morphology and probability maps.Human brain mapping · 2024Article
- Neuromorphological Atlas of Human Prenatal Brain Development: White Paper.Life (Basel, Switzerland) · 2023Article
- Three-Dimensional Crystal Vue Imaging technology assessment of Sylvian fissures at 20-32+6 weeks' normal gestation.European radiology · 2023Article
- Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry.Frontiers in neuroscience · 2023Article
- Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study.Depression and anxiety · 2022Article
- Mapping developmental regionalization and patterns of cortical surface area from 29 post-menstrual weeks to 2 years of age.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Maternal Midpregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorders: A Prenatal Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Method of Reduction Background Fluorescence in Human Fetal Brain Tissue and Quantitative Estimate of the Effect of Photobleaching.Bulletin of experimental biology and medicine · 2021Article
- Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition.Cerebral cortex communications · 2021Article
- Fetal thymus in the middle and late trimesters: Morphometry and development using post-mortem 3.0T MRI.Experimental and therapeutic medicine · 2020Article
- Association of Isolated Congenital Heart Disease with Fetal Brain Maturation.AJNR. American journal of neuroradiology · 2020Article
- NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.The EMBO journal · 2020Article
- Quantitative In vivo MRI Assessment of Structural Asymmetries and Sexual Dimorphism of Transient Fetal Compartments in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Morphometric development of the human fetal cerebellum during the early second trimester.NeuroImage · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
background and purposeFew investigators have analyzed the fetal cerebral cortex with MR imaging of high magnetic strength. Our purpose was to document the sulcal development and obtain quantitative measurements of the fetal brain in the second trimester. MATERIALS AND
methodsThe brains of 69 fetal specimens, with GA 12-22 weeks, were first scanned on a 7T MR imaging scanner. Then the sequential development of the different fissures and sulci was analyzed, and quantitative measurements of the cerebral cortex were obtained.
resultsA new chronology of sulcal development during 12-22 weeks GA was summarized. Before 12 weeks, few sulci were present; by 16 weeks, many sulci were present. The 16th week could be considered the most intensive time point for sulcal emergence. Most sulci, except for the postcentral sulcus and intraparietal sulcus, were present by 22 weeks GA. Measurements of the fetal brains, each with different growth rates, linearly increased with GA, but no sexual dimorphisms or cerebral asymmetries were detected.
conclusionsThe second trimester is the most important phase, during which most sulci are present and can be clearly shown on 7T postmortem MR imaging. It is apparent that the specific time during which neuropathologic features of sulci appear, previously thought to be well understood, should be redefined. Quantitative data provide assistance in the precise understanding of the immature brain. The present results are valuable in anatomic education, research, and assessment of normal brain development in the uterus.
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