ReviewAJNR. American journal of neuroradiology2013
Clinical semiology and neuroradiologic correlates of acute hypernatremic osmotic challenge in adults: a literature review.
Review in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Demyelinating magnetic resonance imaging features in hypernatremic encephalopathy: a case description.Quantitative imaging in medicine and surgery · 2025Article
- Pontine Osmotic Demyelination Syndrome in a Pregnant Woman With Sepsis and Wernicke's Encephalopathy.Cureus · 2024Article
- Postpartum Hypernatremia with Extrapontine Rhabdomyelinolysis: A Case Report.Qatar medical journal · 2022Article
- Diagnosis and treatment of brain injury complicated by hypernatremia.Frontiers in neurology · 2022Review
- Acute Acquired Metabolic Encephalopathy Based on Diffusion MRI.Korean journal of radiology · 2021Review
- Topiramate-induced severe electrolyte abnormalities and hypernatremia leading to central pontine myelinolysis.BMJ case reports · 2021Article
- Fatal case of hospital-acquired hypernatraemia in a neonate: lessons learned from a tragic error.Clinical kidney journal · 2021Article
- Can osmotic demyelination syndrome be a complication of liver failure?eNeurologicalSci · 2020Article
- Pontine Myelinolysis Caused by Hypovolemic Hypernatremia.Case reports in nephrology · 2020Article
- Hypernatremia-induced Neurologic Complications After Hepatic Hydatid Cyst Surgery: Pretreat to Prevent.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Article
- Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy.Child neurology open · 2018Article
- A Case of Osmotic Demyelination Presenting with Severe Hypernatremia.Electrolyte & blood pressure : E & BP · 2015Article
- Plasma exchange successfully treats central pontine myelinolysis after acute hypernatremia from intravenous sodium bicarbonate therapy.BMC nephrology · 2014Article
- Hypernatremia as the Initial Presentation of Osmotic Demyelination Syndrome: A Rare Case with Favorable Neurological Outcome.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex interplay between hypernatremic osmotic disturbances and cerebral lesions is yet to be clarified. In this review, we discuss, on the basis of the reported data of hypernatremic CNS challenge in the adult population, the clinical and radiologic features of the condition. Our search captured 20 case studies and 1 case series with 30 patients in total who acquired acute hypernatremia due to different etiologies and developed CNS lesions. We explored the associations between premorbid conditions, clinical presentation, hypernatremic state, correction rate, and radiologic appearance, including the localization of brain lesions and the outcomes. The results revealed that altered mental status was the most commonly reported symptom and osmotic demyelination syndrome in the form of extrapontine myelinolysis was the prevailing radiologic pattern. Finally, we contrasted, when appropriate, clinical and experimental data related to hypernatremic and hyponatremic osmotic insults to aid the understanding of the pathophysiology of CNS osmotic brain injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.