Evidence map›Paper›PMID 23413108›Full record

ReviewEuropean journal of ophthalmology

Ocular hemodynamics and glaucoma: the role of mathematical modeling.

Alon Harris, Giovanna Guidoboni, Julia C Arciero, Annahita Amireskandari, Leslie A Tobe, Brent A Siesky

Open access · greenAbstract readReview
In one paragraph

Review in European journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Parametric transfer function analysis and modeling of blood flow autoregulation in the optic nerve head.International journal of physiology, pathophysiology and pharmacology · 2014
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alon HarrisDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA. alharris@indiana.edu
Giovanna Guidoboni
Julia C Arciero
Annahita Amireskandari
Leslie A Tobe
Brent A Siesky
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

African and European Descent, Ocular Blood Flow and Glaucoma ProgressionR21EY022101 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI HARRIS, ALON · 2012 to 2013
$419k
NEI NIH HHS 1R21EY022101-01A1NEI NIH HHS R21 EY022101
6 · The paper itself

Abstract

purposeTo discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma.

methodsWe reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation.

resultsMany studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression.

conclusionMathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.

Indexed as

Models, TheoreticalBlood Flow VelocityEyeGlaucoma, Open-AngleHomeostasisHumansOptic DiskOptic Nerve DiseasesRegional Blood Flow

Identifiers

PMID23413108
PMCPMC3683853
OpenAlexW2081837331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.