ArticleGenetics and molecular biology2012
Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining.
Article in Genetics and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Farmers exposed to pesticides have almost five times more DNA damage: a meta-analysis study.Environmental science and pollution research international · 2022Pooled it
- Article
- The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress.Environmental geochemistry and health · 2023Article
- The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity.Biochemical genetics · 2023Article
- Article
- Gestational and Neonatal Outcomes in Cities in the Largest Coal Mining Region in Brazil.International journal of environmental research and public health · 2022Article
- Blood markers among residents from a coal mining area.Environmental science and pollution research international · 2021Article
- Are Our Farm Workers in Danger? Genetic Damage in Farmers Exposed to Pesticides.International journal of environmental research and public health · 2019Article
- Influence of vitamin intake and MTHFR polymorphism on the levels of DNA damage in tobacco farmers.International journal of occupational and environmental health · 2017Article
- Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil.Environmental science and pollution research international · 2017Article
- Biomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals.Safety and health at work · 2016Article
- Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls.BioMed research international · 2016Article
- Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil.Environmental science and pollution research international · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our mutagenesis group has been studying with important economic drivers of our state, such as agriculture, the foot-wear and leather industry and open-cast coal mining. Working conditions in these sectors have potentially harmful to humans. The aim of these studies is to determine the health risk of workers by biomonitoring subjects exposed to genotoxic agents. The main results of our studies with vineyard farmers we observed a high rate of MN and DNA damage in individuals exposed to pesticides (p < 0.001). In addition, some effects of genetic polymorphisms in the modulation of MN results were observed in this group. Tobacco farmers were also evaluated at different crop times. The results showed a significant increase in the Damage index and frequency in tobacco farmers compared to the non-exposed group, for all crop times. The results for footwear and tannery workers showed a significant increase in the mean ID for the solvent-based adhesive (p < 0.001) group in comparison to the water-based adhesive group and control (p < 0.05). For open-cast coal mine workers, the EBCyt indicated a significant increase in nuclear bud frequency and cytokinetic defects in the exposed group compared to the non-exposed group (p < 0.0001). We were able to associate specific genetic susceptibility with each type of exposure and with the non-use or improper use of personal protection equipment and diet adequacy. These results show how important the continuous education of exposed workers is to minimizing the effect of the occupational exposure and the risk of disease associated with the work.
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