Evidence map›Paper›PMID 23412897›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2013

Mechanisms of nasal high flow on ventilation during wakefulness and sleep.

Toby Mündel, Sheng Feng, Stanislav Tatkov, Hartmut Schneider

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02514798 (Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing in Severe COPD Patients), which is not on this map. Cited by 68 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 5 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02514798 nacompletednot on this mapstarted 2015, after this paper: background citation

Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing in Severe COPD Patients

TypeinterventionalSponsorTufts Medical CenterRan2015 to 2018Enrolled11ConditionsCOPDArmsEsophageal and gastric balloons, Respiratory Inductance Plethysmography (RIP) system, Sentec transcutaneous monitoring system, High-flow humidified nasal oxygen delivery system, CPAP (Positive Control)
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Pooled it
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  12. Physiological effects of high-flow nasal cannula therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020
    Trial
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  14. Nasal high flow reduces dead space.Journal of applied physiology (Bethesda, Md. : 1985) · 2017
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  17. Review
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Toby MündelSchool of Sport and Exercise, Massey University, Palmerston North, New Zealand.
Sheng Feng
Stanislav Tatkov
Hartmut Schneider
Fisher & Paykel Healthcare (New Zealand) · NZJohns Hopkins University · USMassey University · NZ

Funding

Sleep Related Mechanisms of COPD ProgressionP50HL084945 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WISE, ROBERT A. · 2007 to 2011
$15.1M
Pathogenesis and Outcomes of Sleep Disordered Breathing in COPDR01HL105546 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SCHNEIDER, HARTMUT · 2011 to 2015
$2.0M
NHLBI NIH HHS HL-105546NHLBI NIH HHS P50-HL-084945-01NHLBI NIH HHS R01 HL105546
6 · The paper itself

Abstract

Nasal high flow (NHF) has been shown to increase expiratory pressure and reduce respiratory rate but the mechanisms involved remain unclear. Ten healthy participants [age, 22 ± 2 yr; body mass index (BMI), 24 ± 2 kg/m(2)] were recruited to determine ventilatory responses to NHF of air at 37°C and fully saturated with water. We conducted a randomized, controlled, cross-over study consisting of four separate ∼60-min visits, each 1 wk apart, to determine the effect of NHF on ventilation during wakefulness (NHF at 0, 15, 30, and 45 liters/min) and sleep (NHF at 0, 15, and 30 liters/min). In addition, a nasal cavity model was used to compare pressure/air-flow relationships of NHF and continuous positive airway pressure (CPAP) throughout simulated breathing. During wakefulness, NHF led to an increase in tidal volume from 0.7 ± 0.1 liter to 0.8 ± 0.2, 1.0 ± 0.2, and 1.3 ± 0.2 liters, and a reduction in respiratory rate (fR) from 16 ± 2 to 13 ± 3, 10 ± 3, and 8 ± 3 breaths/min (baseline to 15, 30, and 45 liters/min NHF, respectively; P < 0.01). In contrast, during sleep, NHF led to a ∼20% fall in minute ventilation due to a decrease in tidal volume and no change in fR. In the nasal cavity model, NHF increased expiratory but decreased inspiratory resistance depending on both the cannula size and the expiratory flow rate. The mechanisms of action for NHF differ from those of CPAP and are sleep/wake-state dependent. NHF may be utilized to increase tidal breathing during wakefulness and to relieve respiratory loads during sleep.

Indexed as

Pulmonary VentilationSleepWakefulnessAirAirway ResistanceContinuous Positive Airway PressureCross-Over StudiesExhalationForced Expiratory VolumeHumansHumidityInhalationModels, AnatomicNasal CavityPressureRespiration, Artificial

Identifiers

PMID23412897
PMCPMC3633436
OpenAlexW2128969083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.