ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Digital twins for chronic lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung.Histochemistry and cell biology · 2021Article
- Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry.Scientific reports · 2020Article
- Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures.Nanomaterials (Basel, Switzerland) · 2019Article
- The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses.Scientific reports · 2019Article
- A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test.PLoS computational biology · 2019Article
- How high resolution 3-dimensional imaging changes our understanding of postnatal lung development.Histochemistry and cell biology · 2018Review
- One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2018Review
- Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers.Computational and mathematical methods in medicine · 2018Article
- Multiscale Lung Imaging Provides New Insights into Disease Progression in the Chronic Obstructive Pulmonary Disease Lung.American journal of respiratory and critical care medicine · 2017Article
- The role of anisotropic expansion for pulmonary acinar aerosol deposition.Journal of biomechanics · 2016Article
- Morphometric differences between central vs. surface acini in A/J mice using high-resolution micro-computed tomography.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- A skeleton-tree-based approach to acinar morphometric analysis using microcomputed tomography with comparison of acini in young and old C57BL/6 mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles.International journal of nanomedicine · 2016Article
- Particle dynamics and deposition in true-scale pulmonary acinar models.Scientific reports · 2015Article
- Improved CT-based estimate of pulmonary gas trapping accounting for scanner and lung-volume variations in a multicenter asthmatic study.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
A registration-based multiscale method to obtain a deforming geometric model of mouse acinus is presented. An intact mouse lung was fixed by means of vascular perfusion at a hydrostatic inflation pressure of 20 cmH(2)O. Microcomputed tomography (μCT) scans were obtained at multiple resolutions. Substructural morphometric analysis of a complete acinus was performed by computing a surface-to-volume (S/V) ratio directly from the 3D reconstruction of the acinar geometry. A geometric similarity is observed to exist in the acinus where S/V is approximately preserved anywhere in the model. Using multiscale registration, the shape of the acinus at an elevated inflation pressure of 25 cmH(2)O is estimated. Changes in the alveolar geometry suggest that the deformation within the acinus is not isotropic. In particular, the expansion of the acinus (from 20 to 25 cmH(2)O) is accompanied by an increase in both surface area and volume in such a way that the S/V ratio is not significantly altered. The developed method forms a useful tool in registration-driven fluid and solid mechanics studies as displacement of the alveolar wall becomes available in a discrete sense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.