ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training With and Without Caloric Restriction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- Isometric slow- and fast-contracting skeletal muscle fibres have more similar cellular and molecular properties at 37°C than at 25°C in older adults.The Journal of physiology · 2026Article
- Ultrasound-guided skeletal muscle biopsy technique permits measurement of structural, functional, cellular and biochemical properties.Scientific reports · 2026Article
- Can a physical activity program improve functional capacity and fatigue in people with cancer? A retrospective analysis.BMC sports science, medicine & rehabilitation · 2025Article
- An optimized approach to study nanoscale sarcomere structure utilizing super-resolution microscopy with nanobodies.PloS one · 2024Article
- Skeletal muscle adaptations in patients with lung cancer: Longitudinal observations from the whole body to cellular level.Journal of cachexia, sarcopenia and muscle · 2023Article
- Article
- Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals.American journal of physiology. Cell physiology · 2023Article
- Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Voluntary exercise does not improve muscular properties or functional capacity during C26-induced cancer cachexia in mice.Journal of muscle research and cell motility · 2021Article
- Phenotypic features of cancer cachexia-related loss of skeletal muscle mass and function: lessons from human and animal studies.Journal of cachexia, sarcopenia and muscle · 2021Review
- Patterns of Sequelae in Women with a History of Localized Breast Cancer: Results from the French VICAN Survey.Cancers · 2021Article
- The Effect of Mechanical Stretch on Myotube Growth Suppression by Colon-26 Tumor-Derived Factors.Frontiers in cell and developmental biology · 2021Article
- Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Effects of an exercise-based oncology rehabilitation program and age on strength and physical function in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Preoperative Peak Oxygen Consumption: A Predictor of Survival in Resected Lung Cancer.Cancers · 2020Article
- Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes.American journal of physiology. Cell physiology · 2019Article
- Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2019Article
- Modeling Human Cancer-induced Cachexia.Cell reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Many patients with cancer experience physical disability following diagnosis, although little is known about the mechanisms underlying these functional deficits. To characterize skeletal muscle adaptations to cancer in humans, we evaluated skeletal muscle structure and contractile function at the molecular, cellular, whole-muscle, and whole-body level in 11 patients with cancer (5 cachectic, 6 noncachectic) and 6 controls without disease. Patients with cancer showed a 25% reduction in knee extensor isometric torque after adjustment for muscle mass (P < 0.05), which was strongly related to diminished power output during a walking endurance test (r = 0.889; P < 0.01). At the cellular level, single fiber isometric tension was reduced in myosin heavy chain (MHC) IIA fibers (P = 0.05) in patients with cancer, which was explained by a reduction (P < 0.05) in the number of strongly bound cross-bridges. In MHC I fibers, myosin-actin cross-bridge kinetics were reduced in patients, as evidenced by an increase in myosin attachment time (P < 0.01); and reductions in another kinetic parameter, myosin rate of force production, predicted reduced knee extensor isometric torque (r = 0.689; P < 0.05). Patients with cancer also exhibited reduced mitochondrial density (-50%; P < 0.001), which was related to increased myosin attachment time in MHC I fibers (r = -0.754; P < 0.01). Finally, no group differences in myofilament protein content or ultrastructure were noted that explained the observed functional alterations. Collectively, our results suggest reductions in myofilament protein function as a potential molecular mechanism contributing to muscle weakness and physical disability in human cancer.
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