ArticleRadiology and oncology2012
Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy.
Article in Radiology and oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Custom bipolar electrode for bleomycin-based electrochemotherapy in patient-derived uveal melanomaFrontiers in cell and developmental biology · 2026Article
- Invasive properties of patient-derived glioblastoma cells after reversible electroporationRadiology and oncology · 2025Article
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- Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study.Endoscopy international open · 2020Article
- Quantitative proteomic analysis of enhanced cellular effects of electrochemotherapy with Cisplatin in triple-negative breast cancer cells.Scientific reports · 2019Article
- Bronchoscopic ablation of peripheral lung tumors.Journal of thoracic disease · 2019Review
- Electrochemotherapy as a New Modality in Interventional Oncology: A Review.Technology in cancer research & treatment · 2018Review
- Treatment of lymph node metastases from gastric cancer with a combination of Irreversible Electroporation and Electrochemotherapy: a case report.Clinical case reports · 2017Article
- Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery.Neuro-oncology · 2016Review
- Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats.Journal of visualized experiments : JoVE · 2016Article
- A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption.Radiology and oncology · 2016Article
- Mathematical Models Describing Chinese Hamster Ovary Cell Death Due to Electroporation In Vitro.The Journal of membrane biology · 2015Article
- Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.Radiology and oncology · 2015Article
- Electrochemotherapy of colorectal liver metastases--an observational study of its effects on the electrocardiogram.Biomedical engineering online · 2015Observational
- [Bioelectric-technology in tumor minimally invasive therapy--from the 11th International Bioelectrics Symposium].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015Article
- Brain metastases in lung adenocarcinoma: impact of EGFR mutation status on incidence and survival.Radiology and oncology · 2014Article
- Different incubation times of cells after gene electrotransfer in fetal bovine serum affect cell viability, but not transfection efficiency.The Journal of membrane biology · 2014Article
- Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases.Cancer cell international · 2014Article
- Electrochemotherapy: from the drawing board into medical practice.Biomedical engineering online · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to the advanced oncological treatments of cancer, an overall increase in cancer incidence, and better diagnostic tools, the incidence of brain metastases is on the rise. This review addresses the current treatment options for patients with multiple brain metastases, presenting electrochemotherapy (ECT) as one of the new experimental treatments for this group of patients.
conclusionsNeurosurgery, stereotactic surgery, and whole-brain radiotherapy are the evidence-based treatments that can be applied for patients with multiple brain metastases. Treatment with chemotherapy and molecularly targeted agents may also be warranted. Several experimental treatments are emerging, one of which is ECT, an effective cancer treatment comprising electric pulses given by electrodes in the tumor tissue, causing electroporation of the cell membrane, and thereby augmenting uptake and the cytotoxicity of the chemotherapeutic drug bleomycin by 300 times. Preclinical data are promising and the first patient has been treated in an ongoing clinical trial for patients with brain metastases. Perspectives for ECT in the brain include treatment of primary and secondary brain tumors as well as soft tissue metastases elsewhere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.