ArticleSurgery today2013
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Article in Surgery today, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: a systematic review and meta-analysis.World journal of gastroenterology · 2015Pooled it
- Pharmacological treatment to reduce pulmonary morbidity after esophagectomy.Annals of gastroenterological surgery · 2021Review
- Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database.Journal of anesthesia · 2019Article
- Prognostic Factors of Salvage Esophagectomy for Residual or Recurrent Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy.World journal of surgery · 2018Article
- Risk factors for pulmonary morbidities after minimally invasive esophagectomy for esophageal cancer.Surgical endoscopy · 2018Article
- Treatment of spontaneous esophageal rupture (Boerhaave syndrome) using thoracoscopic surgery and sivelestat sodium hydrate.Journal of thoracic disease · 2018Article
- Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature.Annals of gastroenterological surgery · 2017Review
- Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.Journal of pharmaceutical health care and sciences · 2016Article
- Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy.Surgery today · 2015Article
- Risk factors for pulmonary complications after esophagectomy for esophageal cancer.Surgery today · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.
methodsPatients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO2/FiO2 ratio (P/F ratio) and postoperative complications were compared between the two groups.
resultsThere were no significant differences between the groups in the patients' background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (p < 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (p < 0.05). There were no differences in any of the other clinical data or complications.
conclusionsPerioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.
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