ArticleJournal of biomedical optics2013
Nonlinear optical microscopy and ultrasound imaging of human cervical structure.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- Assessing preterm risk via label-free, multiparametric imaging of collagen fiber remodeling in the cervix.Biomedical optics express · 2026Article
- Improved imaging interfaces on a co-registered ultrasound and optical microscopy multiscale system.Journal of biomedical optics · 2026Article
- Quantitative Assessment of Collagen Remodeling during a Murine Pregnancy.ACS photonics · 2024Article
- Article
- In vivo Raman spectroscopy monitors cervical change during labor.American journal of obstetrics and gynecology · 2022Article
- Heterogeneous microstructural changes of the cervix influence cervical funneling.Acta biomaterialia · 2022Article
- Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and semantic segmentation classification.Biomedical optics express · 2021Article
- Harnessing non-destructive 3D pathology.Nature biomedical engineering · 2021Review
- Challenges of conducting quantitative ultrasound with a multimodal optical imaging system.Physics in medicine and biology · 2021Article
- An optomechanogram for assessment of the structural and mechanical properties of tissues.Scientific reports · 2021Article
- Evolving cervical imaging technologies to predict preterm birth.Seminars in immunopathology · 2020Review
- 3-D-Printed Registration Phantom for Combined Ultrasound and Optical Imaging of Biological Tissues.Ultrasound in medicine & biology · 2020Article
- Platform for quantitative multiscale imaging of tissue composition.Biomedical optics express · 2020Article
- Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix.Biomedical optics express · 2019Article
- Quantitative Ultrasound Biomarkers Based on Backscattered Acoustic Power: Potential for Quantifying Remodeling of the Human Cervix during Pregnancy.Ultrasound in medicine & biology · 2019Article
- Cervical alterations in pregnancy.Best practice & research. Clinical obstetrics & gynaecology · 2018Review
- Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy.Journal of biomedical optics · 2018Article
- A soft cervix, categorized by shear-wave elastography, in women with short or with normal cervical length at 18-24 weeks is associated with a higher prevalence of spontaneous preterm delivery.Journal of perinatal medicine · 2018Article
- Anisotropy and Spatial Heterogeneity in Quantitative Ultrasound Parameters: Relevance to the Study of the Human Cervix.Ultrasound in medicine & biology · 2018Article
- In vivo Raman spectroscopy for biochemical monitoring of the human cervix throughout pregnancy.American journal of obstetrics and gynecology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The cervix softens and shortens as its collagen microstructure rearranges in preparation for birth, but premature change may lead to premature birth. The global preterm birth rate has not decreased despite decades of research, likely because cervical microstructure is poorly understood. Our group has developed a multilevel approach to evaluating the human cervix. We are developing quantitative ultrasound (QUS) techniques for noninvasive interrogation of cervical microstructure and corroborating those results with high-resolution images of microstructure from second harmonic generation imaging (SHG) microscopy. We obtain ultrasound measurements from hysterectomy specimens, prepare the tissue for SHG, and stitch together several hundred images to create a comprehensive view of large areas of cervix. The images are analyzed for collagen orientation and alignment with curvelet transform, and registered with QUS data, facilitating multiscale analysis in which the micron-scale SHG images and millimeter-scale ultrasound data interpretation inform each other. This novel combination of modalities allows comprehensive characterization of cervical microstructure in high resolution. Through a detailed comparative study, we demonstrate that SHG imaging both corroborates the quantitative ultrasound measurements and provides further insight. Ultimately, a comprehensive understanding of specific microstructural cervical change in pregnancy should lead to novel approaches to the prevention of preterm birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.