Evidence map›Paper›PMID 23412370›Full record

ArticleChemical communications (Cambridge, England)2013

Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

Wenyu Zhang, David I Bryson, Jason B Crumpton, Jessica Wynn, Webster L Santos

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Merging the Versatile Functionalities of Boronic Acid with Peptides.International journal of molecular sciences · 2021
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. An efficient methodology to introduceNew journal of chemistry = Nouveau journal de chimie · 2017
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenyu ZhangDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA.
David I Bryson
Jason B Crumpton
Jessica Wynn
Webster L Santos

Funding

RNA As A Therapeutic TargetR01GM093834 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SANTOS, WEBSTER L · 2010 to 2014
$1.6M
NIGMS NIH HHS R01 GM093834
6 · The paper itself

Abstract

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

Indexed as

Amino Acid SequenceBoronic AcidsHIV-1HumansPeptide LibraryPeptidesProtein BindingRNA, ViralBoronic AcidsPeptide LibraryPeptidesRNA, Viral

Identifiers

PMID23412370
PMCPMC3601739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.