ArticleTransplantation2013
Prior surgery determines islet yield and insulin requirement in patients with chronic pancreatitis.
Article in Transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05095532 (Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- A meta-analysis of the long-term outcomes following surgery or endoscopic therapy for chronic pancreatitis.Langenbeck's archives of surgery · 2022Pooled it
- Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Pooled it
- Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation.Cell transplantation · 2019Trial
- Intraparenchymal Enzyme Injections in Islet Isolations With Incomplete Ductal Perfusion of Enzymes.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Simplified technique in total pancreatectomy with islet cell autotransplantation after Frey's procedure: a case report.Surgical case reports · 2024Article
- Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis.World journal of transplantation · 2023Article
- Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Observational
- Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021Observational
- Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.Endocrine reviews · 2019Review
- Clathrin-mediated Endocytosis of Alpha-1 Antitrypsin is Essential for its Protective Function in Islet Cell Survival.Theranostics · 2019Article
- Glycemic Outcomes of Islet Autotransplantation.Current diabetes reports · 2018Review
- Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis.Current opinion in gastroenterology · 2018Review
- A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT).Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2018Observational
- Autologous Mesenchymal Stem Cell and Islet Cotransplantation: Safety and Efficacy.Stem cells translational medicine · 2018Article
- Total Pancreatectomy With Islet Autotransplantation for Acute Recurrent and Chronic Pancreatitis.Current treatment options in gastroenterology · 2017Review
- Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function.Stem cell research & therapy · 2017Article
- Laparoscopic Total Pancreatectomy With Islet Autotransplantation and Intraoperative Islet Separation as a Treatment for Patients With Chronic Pancreatitis.JAMA surgery · 2017Article
- α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction.Diabetes · 2017Article
- Glycemic Predictors of Insulin Independence After Total Pancreatectomy With Islet Autotransplantation.The Journal of clinical endocrinology and metabolism · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTotal pancreatectomy with islet autotransplantation (TP-IAT) is safe and effective in the management of intractable pain associated with chronic pancreatitis (CP). Prevention of pancreatogenic diabetes after TP-IAT is related to islet yield from the diseased pancreas. The purpose of this study is to compare islet yield and insulin requirement in the 76 patients who underwent different surgical procedures before TP-IAT at the Medical University of South Carolina between 2009 and 2011.
methodsPatients were grouped into four categories based on the operation they had before TP-IAT: transduodenal sphincteroplasty/no prior surgery (n=50), Whipple or Beger procedure (n=14), distal pancreatectomy (n=8), or lateral pancreaticojejunostomy (n=4). Islets were harvested from pancreases of those patients at our current good manufacturing practice facility. Total unpurified islets were transplanted into patients via portal vein infusion. Pancreatic fibrosis, islet yield, cell viability, and insulin requirement were measured.
resultsThe pancreases of transduodenal sphincteroplasty/no prior surgery and Whipple or Beger procedure patients were less fibrotic and had higher islet yield compared with those who had distal pancreatectomy or lateral pancreaticojejunostomy. Higher islet yield also correlated with a greater diabetes-free rate and a lesser insulin requirement at the following intervals: preoperative, postoperative, and 6 months after TP-IAT.
conclusionsPrior surgery is strongly correlated with the extent of pancreatic fibrosis, islet yield, and insulin requirements in CP patients undergoing TP-IAT. The history of prior pancreatic resection and drainage procedures may be used to predict postoperative islet function and help to determine the optimal timing for TP-IAT in CP patients.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.