ReviewCurrent opinion in pulmonary medicine2013
Biomarkers in sepsis.
Review in Current opinion in pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collection of Clinical Specimens From Volunteers for Assay Development
TriVerity in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis
Who cites it
20 citing papers in PubMed.
- Circulating presepsin (soluble CD14 subtype) as a marker of host response in patients with severe sepsis or septic shock: data from the multicenter, randomized ALBIOS trial.Intensive care medicine · 2015Trial
- Multilevel omics for the discovery of biomarkers in pediatric sepsis.Pediatric investigation · 2023Review
- FCGR2C: An emerging immune gene for predicting sepsis outcome.Frontiers in immunology · 2022Article
- A panel of urine-derived biomarkers to identify sepsis and distinguish it from systemic inflammatory response syndrome.Scientific reports · 2021Article
- A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.Scientific reports · 2021Article
- A 33-mRNA Classifier Is Able to Produce Inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis (ORANGES) Trial.Journal of personalized medicine · 2020Article
- Identification of key genes and novel immune infiltration-associated biomarkers of sepsis.Innate immunity · 2020Article
- The Clinical Need for New Diagnostics in the Identification and Management of Patients with Suspected Sepsis in UK NHS Hospitals: A Survey of Healthcare Professionals.Antibiotics (Basel, Switzerland) · 2020Article
- Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints.Shock (Augusta, Ga.) · 2019Review
- To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?Seminars in thrombosis and hemostasis · 2018Review
- Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?Molecular diagnosis & therapy · 2017Review
- Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial.European journal of clinical investigation · 2017Article
- The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages.Frontiers in immunology · 2016Article
- Metabolomics: Applications and Promise in Mycobacterial Disease.Annals of the American Thoracic Society · 2015Review
- Recognizing and managing sepsis: what needs to be done?BMC medicine · 2015Article
- Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.PloS one · 2014Article
- An integrated transcriptome and expressed variant analysis of sepsis survival and death.Genome medicine · 2014Article
- Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases.Frontiers in immunology · 2013Review
- The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level.In vivo (Athens, Greece)Article
- Reactive hyperemia correlates with the presence of sepsis and glycocalyx degradation in the intensive care unit: a prospective cohort study.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purpose of reviewThis review discusses the current developments in biomarkers for sepsis. RECENT
findingsWith quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely revolutionize the management of sepsis. These markers will facilitate early and accurate diagnosis, faster recognition of impending organ dysfunction, optimal selection and titration of appropriate therapies, and more reliable prognostication of risk and outcome. These diagnostics will also enable an improved characterization of the biological phenotype underlying sepsis and thus a better appreciation of the condition. SUMMARY: The potential for novel biomarkers in sepsis will need to be properly realized with considerable funding, academic-industry collaborations, appropriate investigations and validation in heterogenous populations, but these developments do hold the capacity to transform patient care and outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.